Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0052 | 0.0641 | 0.2911 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0752 | 0.0546 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0046 | 0.0531 | 0.2155 |
Brugia malayi | protein-tyrosine kinase | 0.0044 | 0.0481 | 0.1157 |
Loa Loa (eye worm) | SRC-1 | 0.0051 | 0.0622 | 0.0413 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0109 | 0.1818 | 0.2126 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0317 | 0.0101 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0109 | 0.1818 | 0.2126 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0102 | 0.1671 | 1 |
Echinococcus granulosus | cyclin dependent kinase 6 | 0.0176 | 0.3181 | 0.3721 |
Plasmodium falciparum | protein kinase 5 | 0.0046 | 0.0531 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0243 | 0.0688 |
Trichomonas vaginalis | cyclin B3, putative | 0.0032 | 0.0243 | 0.0688 |
Echinococcus multilocularis | cyclins | 0.0032 | 0.0243 | 0.0571 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0051 | 0.0622 | 0.0728 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0102 | 0.1671 | 1 |
Echinococcus multilocularis | cyclins | 0.0032 | 0.0243 | 0.0571 |
Echinococcus multilocularis | neuroglian | 0.0056 | 0.0721 | 0.1691 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0037 | 0.0337 | 0.0394 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0038 | 0.0347 | 0.0815 |
Schistosoma mansoni | cyclins | 0.0032 | 0.0243 | 0.0591 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0034 | 0.028 | 0.0925 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0049 | 0.0589 | 0.9097 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0046 | 0.0531 | 0.032 |
Giardia lamblia | Cyclin A | 0.0032 | 0.0243 | 0.3046 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0044 | 0.0481 | 0.1129 |
Brugia malayi | Fibronectin type III domain containing protein | 0.005 | 0.0606 | 0.1766 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0229 | 0.4261 | 0.4133 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0034 | 0.028 | 0.0254 |
Trichomonas vaginalis | cyclins, putative | 0.0052 | 0.0641 | 0.3281 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0192 | 0.3511 | 0.4107 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0229 | 0.4261 | 0.4983 |
Entamoeba histolytica | protein kinase, putative | 0.0037 | 0.0337 | 0.0653 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0109 | 0.1818 | 0.4267 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0176 | 0.3181 | 0.7728 |
Schistosoma mansoni | vesicular amine transporter | 0.005 | 0.0606 | 0.1473 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0046 | 0.0531 | 0.032 |
Giardia lamblia | Kinase, CMGC CDK | 0.0046 | 0.0531 | 0.8077 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0606 | 0.0397 |
Trichomonas vaginalis | cyclins, putative | 0.0052 | 0.0641 | 0.3281 |
Echinococcus granulosus | cyclin B3 1 | 0.0032 | 0.0243 | 0.0285 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0051 | 0.0622 | 0.146 |
Schistosoma mansoni | tyrosine kinase | 0.0222 | 0.4116 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.007 | 0.1016 | 0.5729 |
Echinococcus granulosus | roundabout 2 | 0.0063 | 0.0866 | 0.1013 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0866 | 0.0663 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0229 | 0.4261 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0102 | 0.1671 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.007 | 0.1016 | 0.5729 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0051 | 0.0622 | 0.146 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.009 | 0.1421 | 0.573 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0034 | 0.028 | 0.068 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0051 | 0.0622 | 0.146 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0044 | 0.0481 | 0.1129 |
Trichomonas vaginalis | cyclin B, putative | 0.0052 | 0.0641 | 0.3281 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0051 | 0.0622 | 0.146 |
Echinococcus multilocularis | Immunoglobulin | 0.005 | 0.0606 | 0.1423 |
Echinococcus multilocularis | cyclin b3 | 0.0032 | 0.0243 | 0.0571 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0099 | 0.1609 | 0.9566 |
Echinococcus multilocularis | Immunoglobulin | 0.005 | 0.0606 | 0.1423 |
Onchocerca volvulus | 0.0052 | 0.0641 | 0.5 | |
Echinococcus multilocularis | cyclins | 0.0032 | 0.0243 | 0.0571 |
Trichomonas vaginalis | cyclins, putative | 0.0032 | 0.0243 | 0.0688 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0051 | 0.0622 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0866 | 0.0663 |
Trichomonas vaginalis | cyclin B, putative | 0.0032 | 0.0243 | 0.0688 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0046 | 0.0531 | 0.1246 |
Echinococcus granulosus | cyclin dependent kinase | 0.0046 | 0.0531 | 0.0621 |
Echinococcus granulosus | tyrosine kinase | 0.0044 | 0.0481 | 0.0563 |
Trypanosoma cruzi | cyclin, putative | 0.0052 | 0.0641 | 0.2911 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0641 | 0.0432 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.1244 | 0.7009 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0046 | 0.0531 | 0.2155 |
Brugia malayi | hypothetical protein | 0.005 | 0.0606 | 0.1766 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0032 | 0.0243 | 0.0571 |
Brugia malayi | cell division control protein 2 homolog | 0.0046 | 0.0531 | 0.1398 |
Loa Loa (eye worm) | TK protein kinase | 0.0044 | 0.0481 | 0.0269 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0192 | 0.3511 | 0.8531 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0046 | 0.0531 | 0.032 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0046 | 0.0531 | 0.2155 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0052 | 0.0641 | 0.1933 |
Trichomonas vaginalis | cyclin B, putative | 0.0052 | 0.0641 | 0.3281 |
Trichomonas vaginalis | cyclin B, putative | 0.0052 | 0.0641 | 0.3281 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0052 | 0.0641 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0046 | 0.0531 | 0.1246 |
Echinococcus multilocularis | roundabout 2 | 0.0063 | 0.0866 | 0.2033 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0034 | 0.028 | 0.0254 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0109 | 0.1818 | 0.4267 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0044 | 0.0481 | 0.0563 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0102 | 0.1671 | 0.6942 |
Echinococcus granulosus | twitchin | 0.0058 | 0.076 | 0.0889 |
Echinococcus granulosus | cyclin B | 0.0052 | 0.0641 | 0.0749 |
Trichomonas vaginalis | cyclin A, putative | 0.0052 | 0.0641 | 0.3281 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0103 | 0.1683 | 0.7002 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0103 | 0.1683 | 0.395 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.0531 | 0.1398 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0064 | 0.0886 | 0.3125 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0066 | 0.0934 | 0.2193 |
Entamoeba histolytica | cyclin, putative | 0.0052 | 0.0641 | 0.2784 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0044 | 0.0481 | 0.1129 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0439 | 0.855 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0052 | 0.0641 | 0.3281 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0046 | 0.0531 | 0.2014 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0934 | 0.0732 |
Leishmania major | cyclin | 0.0052 | 0.0641 | 1 |
Echinococcus granulosus | cyclin b3 | 0.0032 | 0.0243 | 0.0285 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0051 | 0.0622 | 0.0728 |
Loa Loa (eye worm) | TK protein kinase | 0.0037 | 0.0337 | 0.0121 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0046 | 0.0531 | 0.2564 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.005 | 0.0606 | 0.1766 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0052 | 0.0641 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0032 | 0.0243 | 0.0591 |
Schistosoma mansoni | nephrin | 0.0056 | 0.0721 | 0.1751 |
Plasmodium vivax | protein kinase Crk2 | 0.0046 | 0.0531 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.0622 | 0.1512 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0192 | 0.3511 | 0.8241 |
Schistosoma mansoni | tyrosine kinase | 0.0109 | 0.1818 | 0.4417 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0051 | 0.0622 | 0.0728 |
Echinococcus multilocularis | cyclins | 0.0032 | 0.0243 | 0.0571 |
Trypanosoma cruzi | cyclin 6, putative | 0.0052 | 0.0641 | 0.2911 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0053 | 0.0662 | 0.0774 |
Schistosoma mansoni | cell adhesion molecule | 0.0057 | 0.0752 | 0.1827 |
Echinococcus granulosus | cyclins | 0.0032 | 0.0243 | 0.0285 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0046 | 0.0531 | 0.0621 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0606 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0492 | 0.028 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0081 | 0.1244 | 0.7009 |
Brugia malayi | SRC-1 | 0.0051 | 0.0622 | 0.1843 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0052 | 0.0641 | 0.1933 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0034 | 0.028 | 0.0925 |
Trichomonas vaginalis | cyclins, putative | 0.0052 | 0.0641 | 0.3281 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0046 | 0.0531 | 0.0621 |
Echinococcus multilocularis | cyclins | 0.0032 | 0.0243 | 0.0571 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0034 | 0.028 | 0.0925 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0102 | 0.1671 | 1 |
Echinococcus multilocularis | cyclins | 0.0032 | 0.0243 | 0.0571 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0606 | 0.0397 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0057 | 0.0752 | 0.088 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.005 | 0.0606 | 0.1473 |
Loa Loa (eye worm) | TK protein kinase | 0.0115 | 0.1932 | 0.1753 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0046 | 0.0531 | 0.2155 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0066 | 0.0934 | 0.336 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0034 | 0.028 | 0.0426 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0038 | 0.0347 | 0.0406 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0051 | 0.0622 | 0.146 |
Echinococcus multilocularis | cyclin B | 0.0052 | 0.0641 | 0.1504 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0046 | 0.0531 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0606 | 0.0397 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0032 | 0.0243 | 0.0026 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0046 | 0.0531 | 0.6956 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0046 | 0.0531 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0641 | 0.0432 |
Echinococcus granulosus | cyclins | 0.0032 | 0.0243 | 0.0285 |
Trichomonas vaginalis | cyclin D, putative | 0.0032 | 0.0243 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0606 | 0.0397 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0046 | 0.0531 | 0.2014 |
Trichomonas vaginalis | cyclins, putative | 0.0052 | 0.0641 | 0.3281 |
Echinococcus granulosus | cyclins | 0.0032 | 0.0243 | 0.0285 |
Trichomonas vaginalis | cyclin D, putative | 0.0032 | 0.0243 | 0.0688 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0046 | 0.0531 | 0.2564 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0052 | 0.0641 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0046 | 0.0531 | 0.6956 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.0622 | 0.1512 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0115 | 0.1932 | 0.8215 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0051 | 0.0622 | 0.0728 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0102 | 0.1671 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1397 | 0.1206 |
Echinococcus granulosus | Immunoglobulin | 0.005 | 0.0606 | 0.0709 |
Schistosoma mansoni | cyclin B | 0.0052 | 0.0641 | 0.1557 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0051 | 0.0622 | 0.146 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0051 | 0.0622 | 0.0728 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0171 | 0.3084 | 0.293 |
Echinococcus granulosus | cyclins | 0.0032 | 0.0243 | 0.0285 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0051 | 0.0622 | 0.146 |
Giardia lamblia | Hypothetical protein | 0.0032 | 0.0243 | 0.3046 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0051 | 0.0622 | 0.146 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.005 | 0.0606 | 0.1423 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0051 | 0.0622 | 0.0728 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0064 | 0.0886 | 0.0683 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0034 | 0.028 | 0.0177 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0133 | 0.2299 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0046 | 0.0531 | 0.0621 |
Echinococcus multilocularis | cyclins | 0.0032 | 0.0243 | 0.0571 |
Echinococcus granulosus | cyclins | 0.0032 | 0.0243 | 0.0285 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0044 | 0.0481 | 0.0563 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0046 | 0.0531 | 0.129 |
Echinococcus multilocularis | cyclin dependent kinase 6 | 0.0176 | 0.3181 | 0.7466 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0046 | 0.0531 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0606 | 0.0397 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0032 | 0.0243 | 0.0285 |
Echinococcus multilocularis | cyclin B3 1 | 0.0032 | 0.0243 | 0.0571 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.005 | 0.0606 | 0.1473 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0037 | 0.0337 | 0.079 |
Giardia lamblia | Kinase, CMGC CDK | 0.0046 | 0.0531 | 0.8077 |
Trypanosoma cruzi | cyclin, putative | 0.0052 | 0.0641 | 0.2911 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0102 | 0.1671 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0051 | 0.0622 | 0.146 |
Echinococcus granulosus | neuroglian | 0.0056 | 0.0721 | 0.0843 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0046 | 0.0531 | 0.1246 |
Echinococcus granulosus | defective proboscis extension response | 0.005 | 0.0606 | 0.0709 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0046 | 0.0531 | 0.2564 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0066 | 0.0934 | 0.1093 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0045 | 0.0507 | 0.185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.