Detailed information for compound 1516518

Basic information

Technical information
  • TDR Targets ID: 1516518
  • Name: N-[5-(diethylsulfamoyl)-2-methoxyphenyl]-2-me thyl-3-nitrobenzamide
  • MW: 421.467 | Formula: C19H23N3O6S
  • H donors: 1 H acceptors: 5 LogP: 2.8 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(c(c1)NC(=O)c1cccc(c1C)[N+](=O)[O-])OC)CC
  • InChi: 1S/C19H23N3O6S/c1-5-21(6-2)29(26,27)14-10-11-18(28-4)16(12-14)20-19(23)15-8-7-9-17(13(15)3)22(24)25/h7-12H,5-6H2,1-4H3,(H,20,23)
  • InChiKey: ZKKHEQPRMMIYBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[5-(diethylsulfamoyl)-2-methoxy-phenyl]-2-methyl-3-nitro-benzamide
  • STK093978
  • MLS000575269
  • SMR000030469
  • ZINC04675518

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cyclin B3 1 0.0031 0.0265 0.0285
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0097 0.1689 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0042 0.0512 0.0512
Echinococcus multilocularis tyrosine protein kinase Srms 0.0042 0.0502 0.1129
Trichomonas vaginalis cyclins, putative 0.0031 0.0265 0.0688
Echinococcus multilocularis cyclins 0.0031 0.0265 0.0571
Brugia malayi SRC-1 0.0048 0.0643 0.1843
Echinococcus granulosus cyclins 0.0031 0.0265 0.0285
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0239 0.0239
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0301 0.068
Echinococcus multilocularis Immunoglobulin 0.0047 0.0627 0.1423
Entamoeba histolytica protein kinase, putative 0.0035 0.0358 0.0653
Brugia malayi hypothetical protein 0.0047 0.0627 0.1766
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0643 0.0728
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0552 0.2564
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0104 0.1836 0.2126
Onchocerca volvulus 0.0049 0.0661 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0794 0.188
Plasmodium falciparum protein kinase 5 0.0044 0.0552 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0097 0.1701 0.7002
Echinococcus granulosus cyclin dependent kinase 6 0.0167 0.3196 0.3721
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0552 0.0621
Trichomonas vaginalis cyclin D, putative 0.0031 0.0265 0.0688
Echinococcus multilocularis tyrosine protein kinase Blk 0.0042 0.0502 0.1129
Echinococcus granulosus fibroblast growth factor receptor 4 0.0104 0.1836 0.2126
Trichomonas vaginalis cyclins, putative 0.0049 0.0661 0.3281
Schistosoma mansoni tyrosine kinase 0.021 0.4129 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0066 0.1036 0.5729
Loa Loa (eye worm) TK/KIN16 protein kinase 0.006 0.0906 0.0906
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0643 0.0728
Echinococcus granulosus tyrosine protein kinase Lyn 0.005 0.0682 0.0774
Echinococcus multilocularis cyclins 0.0031 0.0265 0.0571
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0369 0.0406
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0085 0.144 0.573
Trypanosoma cruzi CYC2-like cyclin, putative 0.0049 0.0661 0.2911
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0054 0.0772 0.088
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0528 0.185
Echinococcus multilocularis roundabout 2 0.006 0.0886 0.2033
Loa Loa (eye worm) TK/ABL protein kinase 0.0217 0.4273 0.4273
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0661 0.1933
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0097 0.1689 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0066 0.1036 0.5729
Brugia malayi protein-tyrosine kinase 0.0042 0.0502 0.1157
Echinococcus multilocularis neuroglian 0.0053 0.0741 0.1691
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0217 0.4273 1
Echinococcus granulosus cyclins 0.0031 0.0265 0.0285
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0182 0.3526 0.8531
Echinococcus granulosus tyrosine protein kinase ABL1 0.0217 0.4273 0.4983
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0552 0.8077
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0047 0.0627 0.1423
Trichomonas vaginalis cyclin D, putative 0.0031 0.0265 0.0688
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.3196 0.7728
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0643 0.146
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0552 0.1246
Echinococcus granulosus defective proboscis extension response 0.0047 0.0627 0.0709
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0502 0.1129
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0104 0.1836 0.4267
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.0627 0.1766
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0552 0.1246
Trichomonas vaginalis cyclin B, putative 0.0049 0.0661 0.3281
Loa Loa (eye worm) hypothetical protein 0.0049 0.0661 0.0661
Echinococcus multilocularis cyclins 0.0031 0.0265 0.0571
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0552 0.0621
Schistosoma mansoni vesicular amine transporter 0.0047 0.0627 0.1473
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0643 0.146
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.1263 0.7009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0627 0.0627
Trichomonas vaginalis cyclin B, putative 0.0049 0.0661 0.3281
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0094 0.1627 0.9566
Loa Loa (eye worm) hypothetical protein 0.0047 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.006 0.0886 0.0886
Trichomonas vaginalis cyclins, putative 0.0049 0.0661 0.3281
Echinococcus multilocularis cyclin B3 1 0.0031 0.0265 0.0571
Echinococcus multilocularis cyclins 0.0031 0.0265 0.0571
Schistosoma mansoni tyrosine kinase 0.0048 0.0643 0.1512
Trichomonas vaginalis cyclin B, putative 0.0049 0.0661 0.3281
Loa Loa (eye worm) hypothetical protein 0.006 0.0886 0.0886
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0369 0.0815
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0552 0.8077
Schistosoma mansoni tyrosine kinase 0.0104 0.1836 0.4417
Echinococcus granulosus twitchin 0.0055 0.078 0.0889
Echinococcus multilocularis tyrosine protein kinase Abl 0.0097 0.1701 0.395
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0661 0.1933
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0552 0.2014
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0415 0.8553 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0772 0.0772
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0906 0.3125
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0097 0.1689 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0097 0.1689 1
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0552 0.2155
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0063 0.0954 0.2193
Loa Loa (eye worm) hypothetical protein 0.0049 0.0661 0.0661
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0182 0.3526 0.4107
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0552 0.0621
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0047 0.061 0.9097
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0552 0.6956
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0032 0.0301 0.0925
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0552 0.0552
Trypanosoma cruzi cyclin, putative 0.0049 0.0661 0.2911
Echinococcus granulosus Immunoglobulin 0.0047 0.0627 0.0709
Schistosoma mansoni cell adhesion molecule 0.0054 0.0772 0.1827
Echinococcus multilocularis cyclin B 0.0049 0.0661 0.1504
Schistosoma mansoni nephrin 0.0053 0.0741 0.1751
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0265 0.0688
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0643 0.0728
Echinococcus multilocularis cyclins 0.0031 0.0265 0.0571
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0182 0.3526 0.8241
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0104 0.1836 0.4267
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0643 0.146
Giardia lamblia Cyclin A 0.0031 0.0265 0.3046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0794 0.1816
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0301 0.0177
Brugia malayi Protein kinase domain containing protein 0.0044 0.0552 0.1398
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0552 0.1246
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0643 0.0728
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0552 0.6956
Entamoeba histolytica hypothetical protein 0.0077 0.1263 0.7009
Trypanosoma cruzi cyclin, putative 0.0049 0.0661 0.2911
Echinococcus multilocularis cyclins 0.0031 0.0265 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0794 0.188
Entamoeba histolytica cyclin, putative 0.0049 0.0661 0.2784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0794 0.0905
Echinococcus granulosus cyclins 0.0031 0.0265 0.0285
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0063 0.0954 0.1093
Trichomonas vaginalis cyclins, putative 0.0049 0.0661 0.3281
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0031 0.0265 0.0285
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0552 0.2155
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0643 0.146
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0042 0.0502 0.0563
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0552 0.1246
Trypanosoma brucei mitotic cyclin 6 0.0049 0.0661 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0643 0.146
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0643 0.146
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0063 0.0954 0.336
Echinococcus granulosus tyrosine protein kinase Blk 0.0042 0.0502 0.0563
Loa Loa (eye worm) TK protein kinase 0.0035 0.0358 0.0358
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0552 0.0552
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0552 0.129
Echinococcus granulosus cyclin B 0.0049 0.0661 0.0749
Trichomonas vaginalis cyclin A, putative 0.0049 0.0661 0.3281
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0552 0.2155
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0643 0.0728
Trichomonas vaginalis cyclin B, putative 0.0031 0.0265 0.0688
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0794 0.188
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0552 1
Trichomonas vaginalis cyclins, putative 0.0049 0.0661 0.3281
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.0358 0.0394
Loa Loa (eye worm) hypothetical protein 0.0047 0.0627 0.0627
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0794 0.0905
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0552 0.0621
Brugia malayi Immunoglobulin I-set domain containing protein 0.0109 0.195 0.8215
Echinococcus granulosus cyclins 0.0031 0.0265 0.0285
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.0358 0.079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.1689 0.6942
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0265 0.0265
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0643 0.146
Giardia lamblia Hypothetical protein 0.0031 0.0265 0.3046
Loa Loa (eye worm) hypothetical protein 0.0084 0.1416 0.1416
Loa Loa (eye worm) hypothetical protein 0.0047 0.0627 0.0627
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0627 0.1766
Schistosoma mansoni tyrosine kinase 0.0048 0.0643 0.1512
Loa Loa (eye worm) TK protein kinase 0.0109 0.195 0.195
Loa Loa (eye worm) SRC-1 0.0048 0.0643 0.0643
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0097 0.1689 1
Schistosoma mansoni cyclin B 0.0049 0.0661 0.1557
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0643 0.146
Loa Loa (eye worm) phosphatidylinositol 3 0.0162 0.31 0.31
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0032 0.0301 0.0426
Leishmania major cyclin 0.0049 0.0661 1
Echinococcus granulosus cyclins 0.0031 0.0265 0.0285
Echinococcus granulosus neuroglian 0.0053 0.0741 0.0843
Echinococcus granulosus cyclin b3 0.0031 0.0265 0.0285
Trichomonas vaginalis cyclin B3, putative 0.0031 0.0265 0.0688
Loa Loa (eye worm) hypothetical protein 0.0047 0.0627 0.0627
Brugia malayi cell division control protein 2 homolog 0.0044 0.0552 0.1398
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0301 0.0254
Trichomonas vaginalis cyclin B, putative 0.0049 0.0661 0.3281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0794 0.1816
Echinococcus multilocularis cyclin b3 0.0031 0.0265 0.0571
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0301 0.0254
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0032 0.0301 0.0925
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0552 0.2014
Echinococcus multilocularis cyclins 0.0031 0.0265 0.0571
Schistosoma mansoni cyclins 0.0031 0.0265 0.0591
Echinococcus multilocularis Immunoglobulin 0.0047 0.0627 0.1423
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0552 0.2564
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0047 0.0627 0.1473
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0552 0.129
Echinococcus multilocularis cyclin dependent kinase 6 0.0167 0.3196 0.7466
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0643 0.146
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0047 0.0627 0.1473
Loa Loa (eye worm) hypothetical protein 0.0063 0.0954 0.0954
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0643 0.0728
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0552 0.2155
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0552 0.2564
Echinococcus granulosus tyrosine kinase 0.0042 0.0502 0.0563
Giardia lamblia G2/mitotic-specific cyclin B 0.0049 0.0661 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0097 0.1689 1
Plasmodium vivax protein kinase Crk2 0.0044 0.0552 0.5
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0031 0.0265 0.0571
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0794 0.2579
Trypanosoma cruzi cyclin 6, putative 0.0049 0.0661 0.2911
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0049 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0627 0.0627
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.2316 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0552 0.0552
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0032 0.0301 0.0925
Schistosoma mansoni cyclin B3 0.0031 0.0265 0.0591
Echinococcus granulosus roundabout 2 0.006 0.0886 0.1013
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0643 0.0728
Loa Loa (eye worm) TK protein kinase 0.0042 0.0502 0.0502

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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