Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0303 | 0.2957 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0534 | 0.5362 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0231 | 0.2206 | 0.7459 |
Schistosoma mansoni | carbonic anhydrase | 0.0534 | 0.5362 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.1932 | 1 |
Onchocerca volvulus | 0.0182 | 0.1702 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0231 | 0.2206 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0118 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1702 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0534 | 0.5362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0428 | 0.2517 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1932 | 0.3604 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.023 | 0.0429 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0118 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0534 | 0.5362 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.023 | 0.1351 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0118 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.023 | 0.1351 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0534 | 0.5362 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0118 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0428 | 0.2517 |
Brugia malayi | hypothetical protein | 0.003 | 0.0118 | 0.0695 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1932 | 0.1932 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0118 | 0.0695 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0428 | 0.2517 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0118 | 0.0221 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0231 | 0.2206 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0428 | 0.2517 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0118 | 1 |
Brugia malayi | hypothetical protein | 0.0182 | 0.1702 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0118 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1932 | 0.3604 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0118 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0006 | 0.0035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.122 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4581 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3109 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3109 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.1962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.