Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Metabotropic glutamate receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0044 | 0 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0132 | 0.6473 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0147 | 0.7527 | 0.7241 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0132 | 0.6473 | 0.1623 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0096 | 0.3821 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.109 | 0.0061 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0119 | 0.5502 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0123 | 0.579 | 0.5392 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0119 | 0.5502 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0132 | 0.6473 | 0.8079 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0044 | 0 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0132 | 0.6473 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0132 | 0.6473 | 0.8079 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.109 | 0.0061 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0147 | 0.7527 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0126 | 0.6047 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0132 | 0.6473 | 0.1623 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0132 | 0.6473 | 0.6066 |
Leishmania major | DNA topoisomerase ii | 0.0119 | 0.5502 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0167 | 0.8994 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0096 | 0.3821 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0119 | 0.5502 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0044 | 0 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0096 | 0.3821 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0132 | 0.6473 | 0.6375 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3299 | 0.2525 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0132 | 0.6473 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0132 | 0.6473 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0072 | 0.2061 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0132 | 0.6473 | 0.8079 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0132 | 0.6473 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0119 | 0.5502 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3299 | 0.2525 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0133 | 0.6521 | 0.8166 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.