Detailed information for compound 1518625

Basic information

Technical information
  • TDR Targets ID: 1518625
  • Name: 1-[3-[4-(2-methoxyphenyl)piperazin-1-yl]piper idin-1-yl]-3-(1-methylpyrazol-4-yl)propan-1-o ne
  • MW: 411.54 | Formula: C23H33N5O2
  • H donors: 0 H acceptors: 2 LogP: 2.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)C1CCCN(C1)C(=O)CCc1cnn(c1)C
  • InChi: 1S/C23H33N5O2/c1-25-17-19(16-24-25)9-10-23(29)28-11-5-6-20(18-28)26-12-14-27(15-13-26)21-7-3-4-8-22(21)30-2/h3-4,7-8,16-17,20H,5-6,9-15,18H2,1-2H3
  • InChiKey: HQEANRQDQBGQFY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-[4-(2-methoxyphenyl)piperazin-1-yl]-1-piperidyl]-3-(1-methylpyrazol-4-yl)propan-1-one
  • 1-[3-[4-(2-methoxyphenyl)-1-piperazinyl]-1-piperidinyl]-3-(1-methyl-4-pyrazolyl)propan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0398 0.047
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Loa Loa (eye worm) ACC-1 protein 0.0037 0.178 0.3433
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.178 0.2104
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.178 0.3054
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0037 0.178 0.3054
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0017 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Onchocerca volvulus Putative nachr subunit 0.0037 0.178 0.4189
Echinococcus granulosus nAChR subunit 0.002 0.0431 0.051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.178 0.2104
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0205 0.0395
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Onchocerca volvulus 0.0037 0.178 0.4189
Onchocerca volvulus 0.0037 0.178 0.4189
Onchocerca volvulus 0.0065 0.3964 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.8458 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0037 0.178 0.178
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0037 0.178 0.3054
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0017 0.0205 0.0205
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0398 0.0375
Brugia malayi nuclear hormone receptor 0.002 0.0398 0.0375
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0017 0.0205 0.0395
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0398 0.0398
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0398 0.0398
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0037 0.178 0.3433
Brugia malayi Cation transporter family protein 0.0037 0.178 0.3054
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.178 0.178
Schistosoma mansoni coup transcription factor 0.002 0.0398 0.0398
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.178 0.2104
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0398 0.0398
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0398 0.0398
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0037 0.178 0.2104
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.178 0.178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3217 0.3217
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0037 0.178 0.2104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0205 0.0205
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0398 0.0767
Loa Loa (eye worm) hypothetical protein 0.008 0.5183 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0037 0.178 0.178
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.178 0.3054
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0431 0.0439
Echinococcus multilocularis nAChR subunit 0.0037 0.178 0.178
Schistosoma mansoni thyroid hormone receptor 0.0141 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0431 0.0439
Echinococcus multilocularis jun protein 0.0082 0.5361 0.5361
Schistosoma mansoni acetylcholine receptor subunit beta 0.0017 0.0205 0.0205
Brugia malayi hypothetical protein 0.0065 0.3964 0.7291
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.5361 0.6339
Onchocerca volvulus 0.0037 0.178 0.4189
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0398 0.0398
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0037 0.178 0.2104
Onchocerca volvulus 0.002 0.0398 0.0514
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0431 0.0832
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0037 0.178 0.3433
Onchocerca volvulus 0.0037 0.178 0.4189
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0398 0.0375
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0205 0.0205
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0398 0.0375
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0398 0.0767
Onchocerca volvulus 0.002 0.0431 0.0602
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0398 0.0767
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0398 0.0767
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.178 0.3054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0037 0.178 0.3054
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0017 0.0205 0.0205
Schistosoma mansoni jun-related protein 0.0067 0.4143 0.4143
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0037 0.178 0.3433
Echinococcus granulosus nAChR subunit 0.0037 0.178 0.2104
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0398 0.0375
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0037 0.178 0.2104
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Brugia malayi Cation transporter family protein 0.0037 0.178 0.3054
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Schistosoma mansoni nuclear hormone receptor 0.002 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0398 0.0375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3217 0.3217
Schistosoma mansoni hypothetical protein 0.0122 0.8458 0.8458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0398 0.0767
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.178 0.2104
Loa Loa (eye worm) hypothetical protein 0.002 0.0398 0.0767
Schistosoma mansoni nAChR subunit 0.0037 0.178 0.178
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0398 0.047
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0398 0.047
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) acetylcholine receptor protein 0.0017 0.0205 0.0395
Schistosoma mansoni nAChR subunit 0.0037 0.178 0.178
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0398 0.0398
Schistosoma mansoni nAChR subunit 0.0037 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0398 0.0375
Onchocerca volvulus 0.002 0.0431 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0398 0.0375
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0037 0.178 0.3054
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0037 0.178 0.3054
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Brugia malayi steroid hormone receptor 0.002 0.0398 0.0375
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0398 0.047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3217 0.3804
Brugia malayi ecdysteroid receptor 0.002 0.0398 0.0375
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.178 0.3054
Schistosoma mansoni thyroid hormone receptor 0.0141 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0398 0.0375
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0398 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0398 0.0375
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Brugia malayi bZIP transcription factor family protein 0.0082 0.5361 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0398 0.0767
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0431 0.0431
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.5361 0.5361
Echinococcus multilocularis nAChR subunit 0.002 0.0431 0.0431
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0037 0.178 0.2104
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.178 0.178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.178 0.3054
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0205 0.0242
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0398 0.0514
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.4667 0.5517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3217 0.3217
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0398 0.0398
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0398 0.047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0398 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0398 0.0375
Loa Loa (eye worm) hypothetical protein 0.002 0.0398 0.0767
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0431 0.0439
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Brugia malayi nuclear receptor NHR-88 0.002 0.0398 0.0375
Echinococcus granulosus jun protein 0.0082 0.5361 0.6339
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0398 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0398 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0398 0.0375
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.178 0.178
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.178 0.178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.178 0.3054
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.4667 0.4667
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0431 0.0439
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.178 0.178
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0037 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0398 0.047
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.8458 0.8458
Brugia malayi Cation transporter family protein 0.0037 0.178 0.3054
Onchocerca volvulus 0.0037 0.178 0.4189
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0431 0.0431
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0037 0.178 0.178
Entamoeba histolytica hypothetical protein 0.002 0.0431 0.5
Schistosoma mansoni acetylcholine receptor-related 0.0017 0.0205 0.0205
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0398 0.047
Loa Loa (eye worm) ACC-1 protein 0.0037 0.178 0.3433
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.178 0.3054
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.178 0.178
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0037 0.178 0.178
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.3217 0.5842
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0398 0.047
Schistosoma mansoni nAChR subunit 0.0037 0.178 0.178
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0398 0.0398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3217 0.3804
Brugia malayi excitatory GABA receptor EXP-1A 0.0037 0.178 0.3054
Loa Loa (eye worm) hypothetical protein 0.002 0.0398 0.0767
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0398 0.0398
Schistosoma mansoni nAChR subunit 0.0017 0.0205 0.0205
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0431 0.0431
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.178 0.3054
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.178 0.2104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.002 0.0398 0.0767
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0037 0.178 0.3433
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0037 0.178 0.3433
Onchocerca volvulus 0.0037 0.178 0.4189
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0037 0.178 0.2104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Schistosoma mansoni nAChR subunit 0.0017 0.0205 0.0205
Schistosoma mansoni nAChR subunit 0.0037 0.178 0.178
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0398 0.0375
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0398 0.0375
Echinococcus granulosus FTZ F1 alpha 0.002 0.0398 0.047
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0037 0.178 0.178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.178 0.3054
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0398 0.0398
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0037 0.178 0.3433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0398 0.0767
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.178 0.178
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0398 0.0375
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0037 0.178 0.178
Loa Loa (eye worm) LGC-31 protein 0.0037 0.178 0.3433
Loa Loa (eye worm) hypothetical protein 0.002 0.0398 0.0767
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0037 0.178 0.178
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0398 0.0514
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.178 0.2104
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0398 0.0375
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0398 0.0398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3217 0.3217
Schistosoma mansoni hypothetical protein 0.0067 0.4143 0.4143
Schistosoma mansoni nAChR subunit 0.0037 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.002 0.0398 0.0767
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0398 0.0767
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3217 0.3217
Loa Loa (eye worm) hypothetical protein 0.0037 0.178 0.3433
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0398 0.0514
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0037 0.178 0.3054
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.178 0.2104
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0037 0.178 0.3054
Loa Loa (eye worm) hypothetical protein 0.002 0.0398 0.0767
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.3217 0.6207
Schistosoma mansoni nAChR subunit 0.0037 0.178 0.178
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.0017 0.0205 0.0395
Loa Loa (eye worm) hypothetical protein 0.002 0.0431 0.0832
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0017 0.0205 0.0242

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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