Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0113 | 0.066 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0113 | 0.066 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0113 | 0.066 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0744 | 0.8585 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0113 | 0.066 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0113 | 0.066 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0113 | 0.066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.066 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0113 | 0.066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.066 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0857 | 1 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0113 | 0.066 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0113 | 0.066 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0113 | 0.066 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0857 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0113 | 0.066 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0857 | 1 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0744 | 0.8585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.066 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0113 | 0.066 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0857 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.066 | 1 |
Onchocerca volvulus | 0.0113 | 0.066 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.066 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0113 | 0.066 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0113 | 0.066 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0113 | 0.066 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.