Detailed information for compound 1519408

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 455.332 | Formula: C21H14F5NO5
  • H donors: 1 H acceptors: 2 LogP: 5.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC#C[C@@H]([C@H]1OC(=O)NC1=O)c1ccc(cc1)Oc1ccc(cc1OC(F)F)C(F)(F)F
  • InChi: 1S/C21H14F5NO5/c1-2-3-14(17-18(28)27-20(29)32-17)11-4-7-13(8-5-11)30-15-9-6-12(21(24,25)26)10-16(15)31-19(22)23/h4-10,14,17,19H,1H3,(H,27,28,29)/t14-,17-/m1/s1
  • InChiKey: IEYUZLGWSIHESL-RHSMWYFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus free fatty acid receptor 1 Starlite/ChEMBL References
Homo sapiens free fatty acid receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cyclins, putative 0.0051 0.0752 0.3281
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0432
Echinococcus granulosus tyrosine kinase 0.0043 0.0594 0.0676
Loa Loa (eye worm) phosphatidylinositol 3 0.0169 0.3167 0.3167
Schistosoma mansoni voltage-gated potassium channel 0.0051 0.0748 0.1754
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.002 0.0119 0.0245
Trichomonas vaginalis cyclin B, putative 0.0051 0.0752 0.3281
Loa Loa (eye worm) hypothetical protein 0.0062 0.0975 0.0975
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0096 0.1665 0.1927
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.0734 0.1663
Echinococcus multilocularis cyclin B3 1 0.0032 0.0359 0.0795
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0101 0.177 1
Trichomonas vaginalis cyclins, putative 0.0051 0.0752 0.3281
Brugia malayi Immunoglobulin I-set domain containing protein 0.0114 0.2028 0.8472
Echinococcus multilocularis cyclin B 0.0051 0.0752 0.1705
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0734 0.0839
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.002 0.0119 0.0237
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0051 0.0752 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0046 0.0643 0.1454
Echinococcus multilocularis tyrosine protein kinase Blk 0.0043 0.0594 0.134
Schistosoma mansoni cyclins 0.0032 0.0359 0.0822
Echinococcus multilocularis tyrosine protein kinase Srms 0.0043 0.0594 0.134
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0065 0.1042 0.2378
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0643 0.2564
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.005 0.0734 0.1663
Echinococcus multilocularis tyrosine protein kinase HCK 0.0037 0.0452 0.1009
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0032 0.0359 0.0795
Brugia malayi protein-tyrosine kinase 0.0043 0.0594 0.2434
Loa Loa (eye worm) voltage-dependent calcium channel 0.0022 0.0162 0.0162
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0046 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1665
Echinococcus multilocularis cyclin dependent kinase 1 0.0046 0.0643 0.1454
Loa Loa (eye worm) hypothetical protein 0.005 0.0718 0.0718
Echinococcus multilocularis tyrosine protein kinase Src64B 0.005 0.0734 0.1663
Trypanosoma cruzi cyclin, putative 0.0051 0.0752 0.2911
Loa Loa (eye worm) hypothetical protein 0.0065 0.1042 0.1042
Echinococcus multilocularis cyclins 0.0032 0.0359 0.0795
Echinococcus multilocularis cyclin dependent kinase 5 0.0046 0.0643 0.1454
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0101 0.177 1
Trichomonas vaginalis cyclin B, putative 0.0051 0.0752 0.3281
Trypanosoma brucei cdc2-related kinase 3 0.0046 0.0643 0.4726
Echinococcus multilocularis tyrosine protein kinase Fgr 0.005 0.0734 0.1663
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0034 0.0395 0.0925
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0556 0.1988
Schistosoma mansoni tyrosine kinase 0.005 0.0734 0.172
Echinococcus multilocularis cyclin dependent kinase 6 0.0174 0.3262 0.7526
Loa Loa (eye worm) hypothetical protein 0.005 0.0718 0.0718
Echinococcus multilocularis Immunoglobulin 0.005 0.0718 0.1627
Trypanosoma cruzi cdc2-related kinase 3 0.0046 0.0643 0.2155
Echinococcus multilocularis c src tyrosine kinase 0.002 0.0119 0.0237
Loa Loa (eye worm) hypothetical protein 0.0041 0.0544 0.0544
Echinococcus granulosus cyclin b3 0.0032 0.0359 0.0401
Echinococcus granulosus tyrosine protein kinase Blk 0.0043 0.0594 0.0676
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.2391 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.005 0.0734 0.1663
Trypanosoma brucei cdc2-related kinase 1 0.0046 0.0643 0.4726
Trichomonas vaginalis cyclin B, putative 0.0051 0.0752 0.3281
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0096 0.1665 0.3822
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0734 0.1663
Trypanosoma cruzi cyclin, putative 0.0051 0.0752 0.2911
Giardia lamblia Hypothetical protein 0.0032 0.0359 0.3046
Echinococcus granulosus cyclin B3 1 0.0032 0.0359 0.0401
Giardia lamblia G2/mitotic-specific cyclin B 0.0051 0.0752 1
Plasmodium falciparum protein kinase 5 0.0046 0.0643 1
Toxoplasma gondii transporter, cation channel family protein 0.0022 0.0162 0.1833
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0096 0.1665 0.3822
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0734 0.0839
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0049 0.0701 0.9097
Loa Loa (eye worm) hypothetical protein 0.0088 0.15 0.15
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0034 0.0395 0.0254
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0065 0.1042 0.4319
Echinococcus multilocularis neuroglian 0.0055 0.0831 0.1888
Schistosoma mansoni cyclin B3 0.0032 0.0359 0.0822
Loa Loa (eye worm) hypothetical protein 0.0022 0.0162 0.0162
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0034 0.0395 0.0908
Echinococcus multilocularis cyclins 0.0032 0.0359 0.0795
Schistosoma mansoni voltage-gated potassium channel 0.0051 0.0748 0.1754
Schistosoma mansoni tyrosine kinase 0.0108 0.1915 0.4554
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.019 0.3588 0.4177
Trichomonas vaginalis cyclin D, putative 0.0032 0.0359 0.0688
Trichomonas vaginalis cyclins, putative 0.0051 0.0752 0.3281
Trichomonas vaginalis cyclin D, putative 0.0032 0.0359 0.0688
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0046 0.0643 0.0643
Trichomonas vaginalis cyclins, putative 0.0032 0.0359 0.0688
Loa Loa (eye worm) TK protein kinase 0.0043 0.0594 0.0594
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0069 0.1123 0.5729
Brugia malayi Cyclin, N-terminal domain containing protein 0.0051 0.0752 0.3098
Loa Loa (eye worm) hypothetical protein 0.005 0.0718 0.0718
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0046 0.0643 0.0643
Trypanosoma cruzi cdc2-related kinase 1 0.0046 0.0643 0.2155
Trichomonas vaginalis cyclin B, putative 0.0051 0.0752 0.3281
Echinococcus granulosus tyrosine protein kinase HCK 0.0037 0.0452 0.0509
Echinococcus granulosus tyrosine protein kinase Lyn 0.0052 0.0773 0.0884
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0096 0.1665 0.1927
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0047 0.0664 0.2727
Echinococcus granulosus neuroglian 0.0055 0.0831 0.0952
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.005 0.0734 0.0839
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.005 0.0734 0.0839
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0032 0.0359 0.0401
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0017
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0664 0.0757
Echinococcus multilocularis sodium channel protein 0.0042 0.057 0.1284
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0734 0.0839
Trypanosoma cruzi cyclin 6, putative 0.0051 0.0752 0.2911
Schistosoma mansoni tyrosine kinase 0.0019 0.0093 0.0184
Loa Loa (eye worm) hypothetical protein 0.0051 0.0752 0.0752
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0045 0.062 0.185
Trypanosoma cruzi cdc2-related kinase 1 0.0046 0.0643 0.2155
Echinococcus multilocularis voltage dependent calcium channel 0.0096 0.1665 0.3822
Loa Loa (eye worm) TK protein kinase 0.0114 0.2028 0.2028
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.005 0.0734 0.1663
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.008 0.1348 0.7009
Brugia malayi hypothetical protein 0.005 0.0718 0.2955
Loa Loa (eye worm) hypothetical protein 0.005 0.0718 0.0718
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0462 0.1033
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0034 0.0395 0.0426
Echinococcus multilocularis tyrosine protein kinase Abl 0.0101 0.1782 0.4094
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0643 0.2564
Echinococcus multilocularis cyclin dependent kinase 0.0046 0.0643 0.1454
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0065 0.1042 0.1199
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Plasmodium vivax protein kinase Crk2 0.0046 0.0643 0.5
Schistosoma mansoni nephrin 0.0055 0.0831 0.1953
Loa Loa (eye worm) hypothetical protein 0.005 0.0718 0.0718
Echinococcus multilocularis basement membrane specific heparan sulfate 0.005 0.0718 0.1627
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0096 0.1665 0.3953
Toxoplasma gondii hypothetical protein 0.0024 0.0201 0.2495
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0334 0.0334
Echinococcus granulosus cyclins 0.0032 0.0359 0.0401
Schistosoma mansoni vesicular amine transporter 0.0055 0.0826 0.1942
Trypanosoma cruzi CYC2-like cyclin, putative 0.0051 0.0752 0.2911
Brugia malayi Protein kinase domain containing protein 0.0046 0.0643 0.264
Schistosoma mansoni Neurotrimin precursor (hNT) 0.005 0.0718 0.1683
Brugia malayi SRC-1 0.005 0.0734 0.302
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0097
Echinococcus granulosus cyclins 0.0032 0.0359 0.0401
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0034 0.0395 0.0925
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0096 0.1665 0.6941
Brugia malayi Cyclin, N-terminal domain containing protein 0.0051 0.0752 0.3098
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0556 0.1988
Entamoeba histolytica protein kinase, putative 0.0037 0.0452 0.0653
Trichomonas vaginalis cyclins, putative 0.0051 0.0752 0.3281
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0734 0.1663
Trichomonas vaginalis cyclin B, putative 0.0032 0.0359 0.0688
Echinococcus multilocularis cyclins 0.0032 0.0359 0.0795
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0098 0.1708 0.9566
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0734 0.1663
Loa Loa (eye worm) hypothetical protein 0.0044 0.0605 0.0605
Echinococcus granulosus cyclin B 0.0051 0.0752 0.086
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0063 0.0994 0.0994
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0433 0.8567 1
Echinococcus granulosus cyclin dependent kinase 1 0.0046 0.0643 0.0733
Loa Loa (eye worm) hypothetical protein 0.0057 0.0862 0.0862
Trichomonas vaginalis cyclin B3, putative 0.0032 0.0359 0.0688
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0096 0.1665 0.3953
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0664 0.1502
Echinococcus granulosus cyclins 0.0032 0.0359 0.0401
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0096 0.1665 0.3822
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0101 0.177 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0101 0.177 1
Echinococcus granulosus cyclins 0.0032 0.0359 0.0401
Schistosoma mansoni cell adhesion molecule 0.0057 0.0862 0.2028
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0089 0.1523 0.6346
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0057 0.0862 0.0989
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0101 0.177 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0032 0.0359 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0643 0.2564
Echinococcus granulosus fibroblast growth factor receptor 4 0.0108 0.1915 0.2221
Loa Loa (eye worm) calcium channel 0.0096 0.1665 0.1665
Brugia malayi cell division control protein 2 homolog 0.0046 0.0643 0.264
Brugia malayi Fibronectin type III domain containing protein 0.005 0.0718 0.2955
Echinococcus granulosus twitchin 0.0057 0.087 0.0998
Brugia malayi Cyclin, N-terminal domain containing protein 0.0032 0.0359 0.1444
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0059 0.092 1
Echinococcus granulosus roundabout 2 0.0062 0.0975 0.1121
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0994 0.4118
Echinococcus granulosus Immunoglobulin 0.005 0.0718 0.082
Echinococcus granulosus tyrosine protein kinase Src64B 0.005 0.0734 0.0839
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.019 0.3588 0.8567
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0264 0.0264
Schistosoma mansoni tyrosine kinase 0.002 0.0119 0.0245
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0046 0.0643 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0043 0.0594 0.0676
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0047 0.0664 0.0664
Echinococcus multilocularis cyclins 0.0032 0.0359 0.0795
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0034 0.0395 0.0254
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0718 0.2955
Echinococcus multilocularis Immunoglobulin 0.005 0.0718 0.1627
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0643 0.1503
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0359 0.0688
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0594 0.134
Entamoeba histolytica cell division protein kinase 2, putative 0.0046 0.0643 0.2014
Entamoeba histolytica cell division protein kinase 2, putative 0.0046 0.0643 0.2014
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0069 0.1123 0.5729
Echinococcus multilocularis cyclin b3 0.0032 0.0359 0.0795
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0462 0.0521
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.177 0.7383
Onchocerca volvulus 0.0051 0.0752 0.5
Schistosoma mansoni tyrosine kinase 0.002 0.0119 0.0245
Echinococcus multilocularis cyclins 0.0032 0.0359 0.0795
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0395 0.1595
Loa Loa (eye worm) TK protein kinase 0.0037 0.0452 0.0452
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0034 0.0395 0.0925
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.0734 0.0839
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.3262 0.7784
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0101 0.177 1
Brugia malayi Cytochrome P450 family protein 0.0027 0.0264 0.104
Echinococcus granulosus cyclin dependent kinase 0.0046 0.0643 0.0733
Echinococcus granulosus voltage dependent calcium channel 0.0022 0.0162 0.017
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0108 0.1915 0.4403
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0108 0.1915 0.4403
Trypanosoma cruzi cdc2-related kinase 3 0.0046 0.0643 0.2155
Loa Loa (eye worm) hypothetical protein 0.0051 0.0752 0.0752
Echinococcus granulosus defective proboscis extension response 0.005 0.0718 0.082
Entamoeba histolytica hypothetical protein 0.008 0.1348 0.7009
Schistosoma mansoni cyclin B 0.0051 0.0752 0.1764
Loa Loa (eye worm) hypothetical protein 0.0062 0.0975 0.0975
Giardia lamblia Kinase, CMGC CDK 0.0046 0.0643 0.8077
Trypanosoma brucei mitotic cyclin 6 0.0051 0.0752 0.6795
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0643 0.1503
Schistosoma mansoni voltage-gated cation channel 0.0096 0.1665 0.3953
Brugia malayi Tyrosine-protein kinase abl-1 0.0101 0.1782 0.7435
Echinococcus granulosus voltage dependent calcium channel 0.0096 0.1665 0.1927
Leishmania major cyclin 0.0051 0.0752 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0226 0.4329 0.4329
Echinococcus multilocularis voltage dependent calcium channel 0.0096 0.1665 0.3822
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0096 0.1665 0.1927
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0096 0.1665 0.3822
Schistosoma mansoni tyrosine kinase 0.0219 0.4186 1
Trichomonas vaginalis cyclin A, putative 0.0051 0.0752 0.3281
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0042 0.057 0.0648
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0059 0.092 0.4084
Echinococcus granulosus cyclins 0.0032 0.0359 0.0401
Entamoeba histolytica cyclin, putative 0.0051 0.0752 0.2784
Loa Loa (eye worm) SRC-1 0.005 0.0734 0.0734
Schistosoma mansoni tyrosine kinase 0.005 0.0734 0.172
Loa Loa (eye worm) hypothetical protein 0.005 0.0718 0.0718
Echinococcus granulosus c src tyrosine kinase 0.002 0.0119 0.012
Echinococcus granulosus cyclin dependent kinase 6 0.0174 0.3262 0.3796
Echinococcus granulosus tyrosine protein kinase Btk29A 0.002 0.0119 0.012
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0046 0.0643 0.0733
Giardia lamblia Cyclin A 0.0032 0.0359 0.3046
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0108 0.1915 0.2221
Echinococcus granulosus tyrosine protein kinase ABL1 0.0226 0.4329 0.5043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.019 0.3588 0.8283
Echinococcus multilocularis cyclins 0.0032 0.0359 0.0795
Echinococcus multilocularis roundabout 2 0.0062 0.0975 0.2222
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0226 0.4329 1
Echinococcus granulosus cyclin dependent kinase 5 0.0046 0.0643 0.0733
Echinococcus multilocularis cyclins 0.0032 0.0359 0.0795
Giardia lamblia Kinase, CMGC CDK 0.0046 0.0643 0.8077
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.005 0.0718 0.1683

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 7058 nM Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay ChEMBL. 21514824
EC50 (functional) = 7581 nM Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay ChEMBL. 21514824
IC50 (binding) = 2414 nM Inhibition of human GPR40 expressed in CHO cells by SPA based binding assay ChEMBL. 21514824

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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