Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0654 | 0.8917 | 0.8917 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0363 | 0.3926 | 0.4453 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0717 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1502 | 0.1762 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0585 | 0.7735 | 1 |
Echinococcus multilocularis | NMDA receptor | 0.0419 | 0.4891 | 0.4891 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0363 | 0.3926 | 0.3926 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0519 | 0.6611 | 0.6611 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0356 | 0.3808 | 0.3808 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0419 | 0.4891 | 0.4891 |
Echinococcus granulosus | glutamate receptor 2 | 0.0654 | 0.8917 | 0.8917 |
Echinococcus granulosus | glutamate receptor 2 | 0.0519 | 0.6611 | 0.6611 |
Echinococcus granulosus | glutamate receptor 1 | 0.0222 | 0.1502 | 0.1502 |
Schistosoma mansoni | glutamate receptor kainate | 0.0648 | 0.8818 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0419 | 0.4891 | 0.4891 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0585 | 0.7735 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0717 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0419 | 0.4891 | 0.4891 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0717 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0363 | 0.3926 | 0.4966 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0363 | 0.3926 | 0.4453 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0356 | 0.3808 | 0.3808 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0717 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1502 | 0.1762 |
Echinococcus granulosus | glutamate receptor 4 | 0.0222 | 0.1502 | 0.1502 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0222 | 0.1502 | 0.1502 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0363 | 0.3926 | 0.4453 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0585 | 0.7735 | 0.7735 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0363 | 0.3926 | 0.4453 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0654 | 0.8917 | 0.8917 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0432 | 0.5109 | 0.5794 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0585 | 0.7735 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0648 | 0.8818 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0363 | 0.3926 | 0.4453 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0654 | 0.8917 | 0.8917 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0717 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0419 | 0.4891 | 0.4891 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0363 | 0.3926 | 0.3926 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1502 | 0.1762 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 10 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.