Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0472 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.1887 | 0.1887 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0996 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0996 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0571 | 0.1887 | 0.1887 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.1887 | 0.1887 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.1887 | 0.1887 |
Echinococcus granulosus | dihydrofolate reductase | 0.0472 | 0 | 0.5 |
Onchocerca volvulus | 0.0996 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0571 | 0.1887 | 0.1887 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0996 | 1 | 1 |
Onchocerca volvulus | 0.0996 | 1 | 1 | |
Onchocerca volvulus | 0.0996 | 1 | 1 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0472 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0472 | 0 | 0.5 |
Onchocerca volvulus | 0.0996 | 1 | 1 | |
Onchocerca volvulus | 0.0996 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0996 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0571 | 0.1887 | 0.1887 |
Brugia malayi | hypothetical protein | 0.0571 | 0.1887 | 0.1887 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0472 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0571 | 0.1887 | 0.1887 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0571 | 0.1887 | 0.1887 |
Onchocerca volvulus | 0.0996 | 1 | 1 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0472 | 0 | 0.5 |
Onchocerca volvulus | 0.0996 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.1887 | 0.1887 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0571 | 0.1887 | 0.1887 |
Onchocerca volvulus | 0.0996 | 1 | 1 | |
Schistosoma mansoni | dihydrofolate reductase | 0.0472 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.1887 | 0.1887 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Suppression (functional) | = 0 % | In vitro anti-MDR effect in mefloquine resistant TM91C235 cell lines at 500 ng/ml concentration in the presence of 5 ng/mL mefloquine | ChEMBL. | 12061877 |
Suppression (functional) | = 0 % | In vitro anti-MDR effect in mefloquine resistant TM91C235 cell lines at 50 ng/ml concentration in the presence of 5 ng/mL mefloquine | ChEMBL. | 12061877 |
Suppression (functional) | = 0 % | In vitro anti-MDR effect in mefloquine resistant TM91C235 cell lines at 500 ng/ml concentration in the presence of 5 ng/mL mefloquine | ChEMBL. | 12061877 |
Suppression (functional) | = 0 % | In vitro anti-MDR effect in mefloquine resistant TM91C235 cell lines at 50 ng/ml concentration in the presence of 5 ng/mL mefloquine | ChEMBL. | 12061877 |
Suppression (functional) | = 13 % | In vitro anti-MDR effect in chloroquine and mefloquine resistant TM91C235 cell lines at 50 ng/ml concentration | ChEMBL. | 12061877 |
Suppression (functional) | = 13 % | In vitro anti-MDR effect in mefloquine resistant TM91C235 cell lines at 5000 ng/ml concentration in the presence of 5 ng/mL mefloquine | ChEMBL. | 12061877 |
Suppression (functional) | = 13 % | In vitro anti-MDR effect in chloroquine and mefloquine resistant TM91C235 cell lines at 50 ng/ml concentration | ChEMBL. | 12061877 |
Suppression (functional) | = 13 % | In vitro anti-MDR effect in mefloquine resistant TM91C235 cell lines at 5000 ng/ml concentration in the presence of 5 ng/mL mefloquine | ChEMBL. | 12061877 |
Suppression (functional) | = 14 % | In vitro anti-MDR effect in chloroquine resistant TM91C235 cell lines at 50 ng/ml concentration in the presence of 10 ng/mL chloroquine | ChEMBL. | 12061877 |
Suppression (functional) | = 14 % | In vitro anti-MDR effect in chloroquine resistant TM91C235 cell lines at 50 ng/ml concentration in the presence of 10 ng/mL chloroquine | ChEMBL. | 12061877 |
Suppression (functional) | = 18 % | In vitro anti-MDR effect in chloroquine and mefloquine resistant TM91C235 cell lines at 500 ng/ml concentration | ChEMBL. | 12061877 |
Suppression (functional) | = 18 % | In vitro anti-MDR effect in chloroquine and mefloquine resistant TM91C235 cell lines at 500 ng/ml concentration | ChEMBL. | 12061877 |
Suppression (functional) | = 27 % | In vitro anti-MDR effect in chloroquine resistant TM91C235 cell lines at 500 ng/ml concentration in the presence of 10 ng/mL chloroquine | ChEMBL. | 12061877 |
Suppression (functional) | = 27 % | In vitro anti-MDR effect in chloroquine resistant TM91C235 cell lines at 500 ng/ml concentration in the presence of 10 ng/mL chloroquine | ChEMBL. | 12061877 |
Suppression (functional) | = 35 % | In vitro anti-MDR effect in chloroquine and mefloquine resistant TM91C235 cell lines at 5000 ng/ml concentration | ChEMBL. | 12061877 |
Suppression (functional) | = 35 % | In vitro anti-MDR effect in chloroquine and mefloquine resistant TM91C235 cell lines at 5000 ng/ml concentration | ChEMBL. | 12061877 |
Suppression (functional) | = 62 % | In vitro anti-MDR effect in chloroquine resistant TM91C235 cell lines at 5000 ng/ml concentration in the presence of 10 ng/mL chloroquine | ChEMBL. | 12061877 |
Suppression (functional) | = 62 % | In vitro anti-MDR effect in chloroquine resistant TM91C235 cell lines at 5000 ng/ml concentration in the presence of 10 ng/mL chloroquine | ChEMBL. | 12061877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.