Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | oxytocin receptor | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 1B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, putative | 0.0038 | 0.0209 | 0.5 |
Echinococcus multilocularis | CREB binding protein | 0.0084 | 0.1519 | 0.1338 |
Onchocerca volvulus | 0.0056 | 0.0722 | 1 | |
Brugia malayi | TAZ zinc finger family protein | 0.012 | 0.2544 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0611 | 0.3163 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0052 | 0.0611 | 0.3163 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.148 | 0.5818 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.148 | 0.5818 |
Entamoeba histolytica | bromodomain-containing protein | 0.0038 | 0.0209 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0381 | 1 | 1 |
Echinococcus granulosus | bromodomain containing 2 | 0.0082 | 0.148 | 0.0213 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0052 | 0.0611 | 0.3163 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0052 | 0.0611 | 0.3163 |
Entamoeba histolytica | bromodomain-containing protein | 0.0038 | 0.0209 | 0.5 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.012 | 0.2544 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0402 | 0.1515 |
Loa Loa (eye worm) | CBP-B | 0.0085 | 0.1548 | 1 |
Schistosoma mansoni | CREB-binding protein 2 | 0.012 | 0.2544 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0082 | 0.148 | 1 |
Echinococcus granulosus | CREB binding protein | 0.012 | 0.2544 | 0.1435 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0052 | 0.0611 | 0.3163 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0082 | 0.148 | 0.416 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0082 | 0.148 | 0.1298 |
Entamoeba histolytica | bromodomain-containing protein | 0.0038 | 0.0209 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0082 | 0.148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.148 | 0.9493 |
Toxoplasma gondii | bromodomain-containing protein | 0.0038 | 0.0209 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0722 | 0.3831 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0662 | 0.3381 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 320 nM | Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells | ChEMBL. | 21601454 |
Ki (binding) | = 0.18 uM | Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cells | ChEMBL. | 21601454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.