Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0375 | 0.438 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2738 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.1571 | 0.5 |
Brugia malayi | cytochrome b | 0.0375 | 0.438 | 1 |
Plasmodium vivax | cytochrome b | 0.0375 | 0.438 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2738 | 1 |
Toxoplasma gondii | cytochrome b | 0.0375 | 0.438 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.1691 | 0.1027 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 0.2738 | 0.6253 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2738 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2738 | 1 |
Schistosoma mansoni | cytochrome b | 0.0375 | 0.438 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2738 | 1 |
Schistosoma mansoni | cytochrome b | 0.0375 | 0.438 | 0.5 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0252 | 0.2738 | 0.6253 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2738 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0375 | 0.438 | 0.5 |
Echinococcus granulosus | cytochrome B | 0.0375 | 0.438 | 0.5 |
Plasmodium falciparum | cytochrome b | 0.0375 | 0.438 | 0.5 |
Loa Loa (eye worm) | cytochrome b | 0.0375 | 0.438 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.1691 | 0.1027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.