Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1317 | 0.2178 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0 | 0.5 |
Brugia malayi | cation channel family protein | 0.0235 | 0.3861 | 0.3861 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.1921 | 0.1921 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0168 | 0.2555 | 0.2555 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0063 | 0.0515 | 0.0515 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0198 | 0.3143 | 1 |
Onchocerca volvulus | 0.0097 | 0.1162 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0135 | 0.1905 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.2082 | 0.2082 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.6049 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.0205 | 0.3282 | 0.5426 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1233 | 0.2038 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0198 | 0.3143 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0167 | 0.2536 | 0.2536 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0167 | 0.2536 | 0.3186 |
Loa Loa (eye worm) | ryanodine receptor | 0.013 | 0.1808 | 0.2988 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0167 | 0.2536 | 0.3186 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.2082 | 0.2082 |
Schistosoma mansoni | ryanodine receptor related | 0.055 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0167 | 0.2536 | 0.3186 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0347 | 0.6049 | 0.76 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0347 | 0.6049 | 0.76 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0167 | 0.2536 | 0.4192 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0067 | 0.0583 | 0.0583 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0445 | 0.7959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0583 | 0.0964 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0445 | 0.7959 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.