Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1092 | 0.1092 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1092 | 0.1092 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0321 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1092 | 0.1092 |
Schistosoma mansoni | kinase | 0.0293 | 0.9087 | 0.9087 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0136 | 0.3804 | 0.3804 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0109 | 0.2891 | 0.2891 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1092 | 0.1092 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6105 | 0.6105 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0321 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1092 | 0.1092 |
Echinococcus granulosus | geminin | 0.0205 | 0.6105 | 0.6105 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0321 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0321 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0321 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1092 | 0.1092 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0321 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1092 | 0.1092 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0321 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0321 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6105 | 0.6105 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0109 | 0.2891 | 0.2891 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0136 | 0.3804 | 0.3804 |
Giardia lamblia | Kinase, PLK | 0.0321 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1092 | 0.1092 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6105 | 0.6105 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1092 | 0.1092 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0032 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3078 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.