Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0863 | 1 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.075 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0863 | 1 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0863 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.075 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0863 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 9.3 uM | Cytotoxicity against human CEM cells by coulter counter analysis | ChEMBL. | 21366296 |
IC50 (binding) | Inhibition of HIV1 wild type reverse transcriptase expressed in Escherichia coli assessed as incorporation of [3H]dTTP into poly(rA)/oligo(dT) by scintillation counting | ChEMBL. | 21366296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.