Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0146 | 0.1196 | 0.5 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.0912 | 0.7623 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.011 | 0.0761 | 0.6359 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0146 | 0.1196 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1196 | 0.1196 |
Onchocerca volvulus | 0.0146 | 0.1196 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0146 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1196 | 0.1196 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0863 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.1196 | 0.1196 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1196 | 0.1196 |
Echinococcus multilocularis | neuroligin | 0.0146 | 0.1196 | 0.1196 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | carboxylesterase | 0.0863 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0146 | 0.1196 | 0.1196 |
Leishmania major | trypanothione reductase | 0.0048 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.0912 | 0.7623 |
Echinococcus multilocularis | acetylcholinesterase | 0.0863 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0146 | 0.1196 | 0.1196 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0146 | 0.1196 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0146 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0863 | 1 | 1 |
Onchocerca volvulus | 0.0146 | 0.1196 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0863 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0863 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1196 | 0.1196 |
Echinococcus granulosus | carboxylesterase 5A | 0.0863 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0146 | 0.1196 | 0.1196 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0146 | 0.1196 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.0912 | 0.7623 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1196 | 0.1196 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.0912 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0863 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0146 | 0.1196 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.011 | 0.0761 | 0.6359 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0146 | 0.1196 | 0.1196 |
Echinococcus multilocularis | acetylcholinesterase | 0.0863 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0146 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | carboxylesterase | 0.0146 | 0.1196 | 0.1196 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0146 | 0.1196 | 0.1196 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0146 | 0.1196 | 0.1196 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0146 | 0.1196 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.1196 | 0.1196 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.011 | 0.0761 | 0.6359 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.1196 | 0.1196 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.011 | 0.0761 | 0.6359 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0146 | 0.1196 | 0.5 |
Onchocerca volvulus | 0.0146 | 0.1196 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0863 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.011 | 0.0761 | 0.6359 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0863 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1196 | 0.1196 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0863 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.011 | 0.0761 | 0.6359 |
Onchocerca volvulus | 0.0146 | 0.1196 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1196 | 0.1196 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Max response (binding) | = 83 % | Percent maximum response against histamine H2 receptor in guinea pig atrium was evaluated | ChEMBL. | 2931524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.