Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0079 | 0.0944 | 0.0944 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0162 | 0.2259 | 0.2455 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.1497 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.1497 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.1226 | 0.0881 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0114 | 0.1497 | 1 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0043 | 0.0379 | 0.0379 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0114 | 0.1497 | 1 |
Onchocerca volvulus | 0.0043 | 0.0379 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0944 | 0.0971 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0114 | 0.1497 | 0.1162 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0114 | 0.1497 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.2259 | 0.2259 |
Schistosoma mansoni | tyrosine kinase | 0.03 | 0.4454 | 0.4454 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.03 | 0.4454 | 0.5321 |
Loa Loa (eye worm) | ryanodine receptor | 0.0153 | 0.2122 | 0.2994 |
Echinococcus multilocularis | 0.0092 | 0.1156 | 0.1015 | |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0114 | 0.1497 | 0.146 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0162 | 0.2259 | 0.2455 |
Schistosoma mansoni | ryanodine receptor related | 0.0648 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1569 | 0.2045 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0234 | 0.3406 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.1497 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0525 | 0.8038 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0198 | 0.2841 | 0.2841 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.221 | 0.221 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1226 | 0.1226 |
Entamoeba histolytica | protein kinase , putative | 0.0114 | 0.1497 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0242 | 0.354 | 0.543 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0114 | 0.1497 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0114 | 0.1497 | 0.146 |
Giardia lamblia | Aurora kinase | 0.0114 | 0.1497 | 0.5 |
Echinococcus granulosus | insulin receptor | 0.0097 | 0.1226 | 0.1107 |
Brugia malayi | cation channel family protein | 0.0277 | 0.4097 | 0.3864 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0075 | 0.0878 | 0.0878 |
Echinococcus granulosus | aurora kinase A | 0.0114 | 0.1497 | 0.146 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.221 | 0.221 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0114 | 0.1497 | 0.146 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0097 | 0.1226 | 0.1107 |
Toxoplasma gondii | aurora kinase | 0.0114 | 0.1497 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.1497 | 0.1921 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0162 | 0.2259 | 0.2455 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.1497 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0409 | 0.6201 | 0.7602 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1226 | 0.1226 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0114 | 0.1497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.165 | 0.2184 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.2231 | 0.2231 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.1497 | 0.1497 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0097 | 0.1226 | 0.1107 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.03 | 0.4454 | 0.4236 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0234 | 0.3406 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.2259 | 0.2259 |
Entamoeba histolytica | protein kinase, putative | 0.0114 | 0.1497 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0409 | 0.6201 | 0.7602 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0114 | 0.1497 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 0.6201 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.1497 | 0.1921 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0525 | 0.8038 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0159 | 0.2215 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.1497 | 0.1921 |
Schistosoma mansoni | protein kinase | 0.0114 | 0.1497 | 0.1497 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.221 | 0.221 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0097 | 0.1226 | 0.1456 |
Echinococcus granulosus | epidermal growth factor receptor | 0.03 | 0.4454 | 0.5321 |
Entamoeba histolytica | protein kinase, putative | 0.0114 | 0.1497 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.03 | 0.4454 | 0.7 |
Echinococcus multilocularis | insulin receptor | 0.0097 | 0.1226 | 0.1107 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0114 | 0.1497 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0114 | 0.1497 | 0.1162 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.8 uM | Activation of UTRN promoter in mouse H2K cells assessed as upregulation of UTRN production after 48 hrs by luciferase reporter linked assay | ChEMBL. | 21456623 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 21456623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.