Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ryanodine receptor related | 0.0493 | 1 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0151 | 0.1508 | 0.0785 |
Loa Loa (eye worm) | ryanodine receptor | 0.0116 | 0.0655 | 0.1193 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0178 | 0.2179 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.5494 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0184 | 0.2338 | 0.4255 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0178 | 0.2179 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0399 | 0.7672 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0096 | 0.0175 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0399 | 0.7672 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0121 | 0.0767 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21.1 uM | Inhibition of human HDAC3 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | = 29.4 uM | Inhibition of human HDAC8 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | = 53.7 uM | Inhibition of human HDAC9 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | = 80.9 uM | Inhibition of human HDAC7 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | = 89.3 uM | Inhibition of human HDAC1 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC4 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC5 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC6 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC10 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC11 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.