Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ryanodine receptor | 0.0127 | 0.0655 | 0.1193 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0165 | 0.1508 | 0.0785 |
Schistosoma mansoni | ryanodine receptor related | 0.054 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0132 | 0.0767 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0437 | 0.7672 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0096 | 0.0175 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0437 | 0.7672 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0195 | 0.2179 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.0202 | 0.2338 | 0.4255 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0195 | 0.2179 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.5494 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 36 % | Insulin sensitizing activity in mouse 3T3L1 cells assessed as triglyceride accumulation at 1 uM by insulin-regulated cell differentiation assay relative to rosiglitazone | ChEMBL. | 19423341 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.