Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.1161 | 0.6636 |
Brugia malayi | ADAMTS-like protease | 0.0067 | 0.1641 | 0.1641 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0063 | 0.1399 | 0.4696 |
Brugia malayi | angiogenesis inhibito | 0.0067 | 0.1641 | 0.1641 |
Brugia malayi | hypothetical protein | 0.0063 | 0.1399 | 0.1399 |
Onchocerca volvulus | Papilin homolog | 0.0069 | 0.1749 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 0.3218 | 1 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0091 | 0.2979 | 0.8685 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0091 | 0.2979 | 0.8685 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0096 | 0.3218 | 1 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.1451 | 0.1451 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1399 | 0.0269 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.1451 | 0.0328 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.1161 | 0.6636 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0091 | 0.2979 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1749 | 0.0666 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 30 ml/min.kg | Clearance in mouse | ChEMBL. | 21536437 |
CL (ADMET) | < 2 uL/min/10^6cells | Intrinsic clearance in human hepatocytes measured per million cells | ChEMBL. | 21536437 |
F (ADMET) | = 0.62 % | Absolute bioavailability in mouse | ChEMBL. | 21536437 |
F (ADMET) | = 54 % | Oral bioavailability in mouse | ChEMBL. | 21536437 |
Fu (ADMET) | > 50 % | Free drug level in human | ChEMBL. | 21536437 |
IC50 (binding) | = 26 nM | Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | = 860 nM | Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 23000 nM | Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 23000 nM | Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 25000 nM | Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 31000 nM | Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10 uM | Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 100 uM | Inhibition of human ERG | ChEMBL. | 21536437 |
Inhibition (ADMET) | Inhibition of CYP3A4 | ChEMBL. | 21536437 | |
Inhibition (ADMET) | Inhibition of CYP2D6 | ChEMBL. | 21536437 | |
Inhibition (ADMET) | Inhibition of CYP2C9 | ChEMBL. | 21536437 | |
Inhibition (ADMET) | Inhibition of CYP2C19 | ChEMBL. | 21536437 | |
Inhibition (ADMET) | Inhibition of CYP1A2 | ChEMBL. | 21536437 | |
Papp (ADMET) | = 8.3 10'-6 cm/s | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM | ChEMBL. | 21536437 |
T1/2 (ADMET) | = 2.6 hr | Half life in mouse | ChEMBL. | 21536437 |
Vdss (ADMET) | = 2.5 L/Kg | Volume of distribution at steady state in mouse | ChEMBL. | 21536437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.