Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | plexin A | 0.0025 | 0.006 | 0.0478 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1812 | 0.8677 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0275 | 0.1265 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0275 | 0.1265 | 0.5 |
Brugia malayi | plexin A | 0.0025 | 0.006 | 0.0151 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0275 | 0.1265 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.2086 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0042 | 0.0332 |
Schistosoma mansoni | amine oxidase | 0.0275 | 0.1265 | 0.1265 |
Onchocerca volvulus | 0.0275 | 0.1265 | 1 | |
Leishmania major | UDP-galactopyranose mutase | 0.0275 | 0.1265 | 0.5 |
Schistosoma mansoni | plexin | 0.0021 | 0.0042 | 0.0042 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.2086 | 1 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0275 | 0.1265 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0275 | 0.1265 | 0.1265 |
Brugia malayi | SWIRM domain containing protein | 0.0275 | 0.1265 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.2086 | 1 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0275 | 0.1265 | 0.1398 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1812 | 0.8677 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.2086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1265 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0275 | 0.1265 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1265 | 1 |
Brugia malayi | hypothetical protein | 0.0275 | 0.1265 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0275 | 0.1265 | 0.5 |
Echinococcus multilocularis | 0.0275 | 0.1265 | 0.1212 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0275 | 0.1265 | 0.1398 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0275 | 0.1265 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0275 | 0.1265 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1265 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0275 | 0.1265 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1265 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0275 | 0.1265 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0275 | 0.1265 | 0.1265 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0275 | 0.1265 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1265 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0275 | 0.1265 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0275 | 0.1265 | 0.1212 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12.7 uM | Inhibition of purified recombinant c-Met after 60 mins by ELISA | ChEMBL. | 21405128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.