Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1536 | 0.3586 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0347 | 0.0712 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.1536 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0347 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1014 | 0.1122 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0256 | 0.0237 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0256 | 0.0491 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.1536 | 0.3586 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0347 | 0.0344 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1536 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0347 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.1536 | 0.3667 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0112 | 0.4189 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0347 | 0.0712 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.1536 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0347 | 0.0829 |
Brugia malayi | Peptidase family M28 containing protein | 0.0112 | 0.4189 | 0.4829 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1536 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1536 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.8618 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0112 | 0.4189 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0112 | 0.4189 | 0.4158 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.4189 | 0.4829 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0256 | 0.0237 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0347 | 0.0712 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.8618 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1014 | 0.1122 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1014 | 0.1122 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0347 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0347 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1014 | 0.1122 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.1536 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0053 | 0.0126 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1536 | 0.3586 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0053 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0112 | 0.4189 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.