TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 514.139 | Formula: C31H44ClNO3
H donors: 2 H acceptors: 2 LogP: 6.73 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: C1CCC(CC1)NC1CCCCC1.OC(=O)C(Oc1ccc(cc1)C(C)C)CCc1ccc(cc1)Cl
InChi: 1S/C19H21ClO3.C12H23N/c1-13(2)15-6-10-17(11-7-15)23-18(19(21)22)12-5-14-3-8-16(20)9-4-14;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h3-4,6-11,13,18H,5,12H2,1-2H3,(H,21,22);11-13H,1-10H2
InChiKey: JITBNOFLSCBQSW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	putative neuropeptide receptor	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Brugia malayi	hypothetical protein	0.0358	0.5199	0.5199
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Brugia malayi	ecdysone receptor	0.032	0.4623	0.4623
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0017	0.0075	0.0075
Schistosoma mansoni	thyroid hormone receptor	0.0678	1	1
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0045	0.0493	0.042
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0493	0.042
Trypanosoma brucei	hexokinase, putative	0.0037	0.0382	0.5
Brugia malayi	Melatonin receptor type 1A	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	nuclear hormone receptor	0.0678	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	nuclear receptor	0.032	0.4623	0.4582
Brugia malayi	neuropeptide F receptor	0.0017	0.0075	0.0075
Brugia malayi	Nuclear hormone receptor E75	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	nuclear receptor NHR-67	0.032	0.4623	0.4623
Schistosoma mansoni	hypothetical protein	0.0045	0.0493	0.042
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0017	0.0075	0.0075
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Onchocerca volvulus		0.0023	0.0173	0.0099
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.032	0.4623	0.4582
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hexokinase	0.0037	0.0382	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0678	1	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.032	0.4623	0.4623
Echinococcus granulosus	thyroid hormone receptor alpha	0.032	0.4623	0.4582
Onchocerca volvulus		0.032	0.4623	0.4582
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0075	0.0075
Onchocerca volvulus	Hexokinase homolog	0.0023	0.0173	0.0099
Echinococcus multilocularis	hexokinase	0.0037	0.0382	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	melatonin receptor type 1A	0.0017	0.0075	0.0075
Onchocerca volvulus		0.032	0.4623	0.4582
Echinococcus multilocularis	nuclear receptor nhr 48	0.032	0.4623	0.4582
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.032	0.4623	0.4582
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0045	0.0493	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0678	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0358	0.5199	0.5199
Onchocerca volvulus		0.0045	0.0493	0.042
Loa Loa (eye worm)	trypsin family protein	0.0045	0.0493	0.0493
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0678	1	1
Plasmodium vivax	hexokinase, putative	0.0037	0.0382	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0678	1	1
Schistosoma mansoni	hexokinase	0.0037	0.0382	0.0309
Brugia malayi	Nuclear hormone receptor-like 1	0.0358	0.5199	0.5199
Treponema pallidum	hexokinase (hxk)	0.0037	0.0382	0.5
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Brugia malayi	conserved hypotetical protein	0.032	0.4623	0.4623
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0493	0.042
Onchocerca volvulus		0.0045	0.0493	0.042
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Echinococcus multilocularis	ecdysone induced protein 78C	0.0678	1	1
Echinococcus granulosus	Mastin	0.0045	0.0493	0.042
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Onchocerca volvulus		0.0045	0.0493	0.042
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Brugia malayi	Dopamine receptor protein 2	0.0017	0.0075	0.0075
Brugia malayi	nuclear receptor NHR-88	0.032	0.4623	0.4623
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0493	0.042
Brugia malayi	steroid hormone receptor	0.0678	1	1
Echinococcus granulosus	transmembrane protease serine 3	0.0045	0.0493	0.042
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0678	1	1
Onchocerca volvulus		0.0045	0.0493	0.042
Schistosoma mansoni	nuclear hormone receptor	0.032	0.4623	0.4582
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0358	0.5199	0.5162
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Echinococcus granulosus	hexokinase	0.0037	0.0382	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0204	0.0204
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0678	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0678	1	1
Schistosoma mansoni	nuclear receptor nhr-48	0.032	0.4623	0.4582
Brugia malayi	hypothetical protein	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Onchocerca volvulus	Protein ultraspiracle homolog	0.0678	1	1
Brugia malayi	G protein-coupled receptor	0.0017	0.0075	0.0075
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0358	0.5199	0.5199
Loa Loa (eye worm)	hypothetical protein	0.0358	0.5199	0.5199
Brugia malayi	Nuclear hormone receptor E75	0.032	0.4623	0.4623
Brugia malayi	ORL1-like opioid receptor	0.0017	0.0075	0.0075
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Schistosoma mansoni	retinoic acid receptor RXR	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0678	1	1
Brugia malayi	nuclear hormone receptor	0.0678	1	1
Schistosoma mansoni	zinc finger protein	0.032	0.4623	0.4582
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0358	0.5199	0.5162
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.031	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.032	0.4623	0.4582
Brugia malayi	sulfakinin receptor protein	0.0017	0.0075	0.0075
Plasmodium falciparum	hexokinase	0.0037	0.0382	0.5
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0678	1	1
Loa Loa (eye worm)	hexokinase	0.0037	0.0382	0.0382
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.032	0.4623	0.4582
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0017	0.0075	0.0075
Echinococcus granulosus	ecdysone induced protein 78C	0.0678	1	1
Schistosoma mansoni	nuclear hormone receptor	0.032	0.4623	0.4582
Brugia malayi	Dopamine receptor	0.0017	0.0075	0.0075
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0392	0.0319
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0358	0.5199	0.5199
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0358	0.5199	0.5199
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0045	0.0493	0.042
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0045	0.0493	0.042
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Brugia malayi	G protein-coupled receptor F59B2.13	0.0017	0.0075	0.0075
Onchocerca volvulus	Bile acid receptor homolog	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	Serotonin receptor	0.0017	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0045	0.0493	0.0493
Brugia malayi	nuclear receptor RXR	0.032	0.4623	0.4623
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0678	1	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0045	0.0493	0.042
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.032	0.4623	0.4582
Brugia malayi	Hexokinase family protein	0.0023	0.0173	0.0173
Echinococcus granulosus	glycoprotein Antigen 5	0.0045	0.0493	0.042
Schistosoma mansoni	nuclear receptor	0.032	0.4623	0.4582
Brugia malayi	Dopamine receptor protein 1	0.0017	0.0075	0.0075
Trypanosoma brucei	hexokinase	0.0037	0.0382	0.5
Onchocerca volvulus		0.0045	0.0493	0.042
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0678	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0678	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0678	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0017	0.0075	0.0075
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0678	1	1
Brugia malayi	Trypsin family protein	0.0045	0.0493	0.0493
Onchocerca volvulus		0.0037	0.0382	0.0309
Loa Loa (eye worm)	TYRA-2 protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Brugia malayi	RE15519p	0.0017	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	Nuclear hormone receptor-like 1	0.0358	0.5199	0.5199
Brugia malayi	hypothetical protein	0.0358	0.5199	0.5199
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0678	1	1
Schistosoma mansoni	hypothetical protein	0.0045	0.0493	0.042
Echinococcus multilocularis	hexokinase	0.0037	0.0382	0.0309
Onchocerca volvulus		0.0678	1	1
Brugia malayi	GnHR receptor homolog	0.0017	0.0075	0.0075
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0678	1	1
Mycobacterium ulcerans	hypothetical protein	0.0045	0.0493	0.5
Leishmania major	hexokinase, putative	0.0037	0.0382	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0017	0.0075	0.0075
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.032	0.4623	0.4582
Brugia malayi	photoreceptor-specific nuclear receptor	0.0678	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0678	1	1
Onchocerca volvulus		0.0037	0.0382	0.0309
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.032	0.4623	0.4582
Echinococcus multilocularis	enteropeptidase	0.0045	0.0493	0.042
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0493	0.042
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0035	0.0344	0.0271
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0017	0.0075	0.0075
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0678	1	1
Trypanosoma brucei	hexokinase	0.0037	0.0382	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.032	0.4623	0.4623
Brugia malayi	tailless protein	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.032	0.4623	0.4582
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.031	0.5
Loa Loa (eye worm)	hypothetical protein	0.0358	0.5199	0.5199
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.032	0.4623	0.4582
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0678	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0035	0.0344	0.0344
Schistosoma mansoni	thyroid hormone receptor	0.0678	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0035	0.0344	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	hypothetical protein	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0678	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0493	0.042
Echinococcus granulosus	hexokinase type 2	0.0037	0.0382	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	Serotonin receptor	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0493	0.042
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0678	1	1
Echinococcus granulosus	enteropeptidase	0.0045	0.0493	0.042
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0493	0.042
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.003	0.0275	0.0275
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0017	0.0075	0.0075
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Schistosoma mansoni	coup transcription factor	0.0678	1	1
Brugia malayi	hexokinase	0.0037	0.0382	0.0382
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.032	0.4623	0.4582
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Echinococcus multilocularis	glycoprotein Antigen 5	0.0045	0.0493	0.042
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0017	0.0075	0.0075
Brugia malayi	G-protein coupled receptor	0.0017	0.0075	0.0075
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0678	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0678	1	1
Echinococcus multilocularis	hexokinase type 2	0.0037	0.0382	0.0309
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Trypanosoma cruzi	hexokinase, putative	0.0037	0.0382	0.5
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0678	1	1
Brugia malayi	Trypsin family protein	0.0045	0.0493	0.0493
Echinococcus granulosus	FTZ F1 alpha	0.0678	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0678	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0392	0.0319
Brugia malayi	nuclear receptor NHR-67	0.032	0.4623	0.4623
Echinococcus multilocularis	Mastin	0.0045	0.0493	0.042
Brugia malayi	AKH receptor	0.0017	0.0075	0.0075
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Leishmania major	hexokinase, putative	0.0037	0.0382	0.5
Brugia malayi	Trypsin-like protease protein 5	0.0045	0.0493	0.0493
Echinococcus multilocularis	transmembrane protease serine 3	0.0045	0.0493	0.042
Brugia malayi	hypothetical protein	0.0017	0.0075	0.0075
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.032	0.4623	0.4582
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0678	1	1
Brugia malayi	Trypsin family protein	0.0045	0.0493	0.0493
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0493	0.042
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Entamoeba histolytica	hexokinase 1	0.0037	0.0382	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0017	0.0075	0.0075
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0678	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0678	1	1
Echinococcus granulosus	hexokinase	0.0037	0.0382	0.0309
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Brugia malayi	nuclear receptor RXR	0.0358	0.5199	0.5199
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0678	1	1
Brugia malayi	G-protein coupled receptor	0.0017	0.0075	0.0075
Brugia malayi	putative neuropeptide receptor NPR1	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0358	0.5199	0.5162
Brugia malayi	orphan nuclear receptor NR2E1	0.032	0.4623	0.4623
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0678	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0678	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0017	0.0075	0.0075
Loa Loa (eye worm)	nuclear hormone receptor	0.032	0.4623	0.4623
Toxoplasma gondii	hexokinase	0.0037	0.0382	0.5
Brugia malayi	nuclear hormone receptor	0.032	0.4623	0.4623
Onchocerca volvulus		0.0037	0.0382	0.0309
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.032	0.4623	0.4582
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	neuropeptide F receptor	0.0017	0.0075	0.0075
Echinococcus granulosus	Nuclear hormone receptor HR96	0.032	0.4623	0.4582
Onchocerca volvulus		0.0045	0.0493	0.042
Brugia malayi	Trypsin family protein	0.0045	0.0493	0.0493
Brugia malayi	Hexokinase family protein	0.0037	0.0382	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Brugia malayi	nuclear receptor NHR-88	0.0678	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0358	0.5199	0.5162
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0678	1	1
Loa Loa (eye worm)	hexokinase	0.0023	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.032	0.4623	0.4623
Trypanosoma cruzi	hexokinase, putative	0.0037	0.0382	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0678	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0678	1	1
Entamoeba histolytica	hexokinase 2	0.0037	0.0382	0.5
Loa Loa (eye worm)	hexokinase type II	0.0037	0.0382	0.0382
Brugia malayi	Nuclear hormone receptor-like 1	0.0678	1	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.032	0.4623	0.4623
Loa Loa (eye worm)	DR-78	0.032	0.4623	0.4623
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0678	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0075	0.0075
Echinococcus granulosus	Nuclear hormone receptor HR96	0.032	0.4623	0.4582
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Brugia malayi	Steroid receptor seven-up type 2	0.0678	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0678	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0035	0.0344	0.0344
Brugia malayi	larval opioid receptor	0.0017	0.0075	0.0075
Echinococcus multilocularis	hexokinase	0.0037	0.0382	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0493	0.042
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0017	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0075
Echinococcus granulosus	hexokinase	0.0037	0.0382	0.0309

Activities

Activity type	Activity value	Assay description	Source	Reference
Basal uptake (functional)	= 89 %	compound was evaluated for their acute effects in vitro by measuring 2-Deoxyglucose (2DG) uptake in vehicle treated 3T3-L1 adipocytes at 100 uM dose.	ChEMBL.	8941393
Hypoglycemic activity (functional)	= 64 %	compound was tested in vivo for hypoglycemic activity in 6-8 week old C57BL/6J ob/ob mouse at 25 mg/kg	ChEMBL.	8941393

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1744421

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1523658