Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0687 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0791 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0687 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0791 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0791 | 1 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0791 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 23 mm | Antibacterial activity against Escherichia coli at 10 ug/disc after 24 hrs by disc diffusion method | ChEMBL. | 21481990 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.