Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0933 | 0.2706 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.3337 | 0.3337 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.123 | 0.3294 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.123 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.068 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0584 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.123 | 0.123 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0584 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.068 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.123 | 0.3294 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0933 | 0.2706 |
Loa Loa (eye worm) | acetyltransferase | 0.0149 | 0.3447 | 0.3523 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.123 | 0.123 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0933 | 0.0954 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.123 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.123 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0149 | 0.3447 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.123 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.068 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0149 | 0.3447 | 0.3447 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 0.9784 | 1 |
Echinococcus multilocularis | hedgehog | 0.022 | 0.5304 | 0.5304 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0149 | 0.3447 | 0.9229 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.068 | 0.068 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0488 | 0.1308 |
Echinococcus multilocularis | smoothened | 0.0399 | 1 | 1 |
Echinococcus granulosus | Desert hedgehog protein | 0.022 | 0.5304 | 0.5304 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0584 | 0.5 |
Brugia malayi | Hint module family protein | 0.006 | 0.1097 | 0.3182 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0933 | 0.0954 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1097 | 0.1121 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1097 | 0.1121 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0488 | 0.0499 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.3735 | 1 |
Brugia malayi | Hint module family protein | 0.006 | 0.1097 | 0.3182 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.123 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.123 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0488 | 0.1417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.