Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0316 | 0.5214 | 0.5214 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0316 | 0.5214 | 0.8099 |
Onchocerca volvulus | 0.0102 | 0 | 0.5 | |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0366 | 0.6438 | 1 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0316 | 0.5214 | 0.8099 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0366 | 0.6438 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | Antiplasmodial activity against Plasmodium falciparum W2 | ChEMBL. | 21376591 |
Inhibition (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 10 ug/ml by BACTEC radiometric susceptibility assay | ChEMBL. | 21376591 | |
Inhibition (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 1 ug/ml by BACTEC radiometric susceptibility assay | ChEMBL. | 21376591 | |
MIC (functional) | = 15.5 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay | ChEMBL. | 21376591 |
MIC (functional) | = 57.1 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv by LORA assay | ChEMBL. | 21376591 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.