Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Sodium/hydrogen exchanger 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | telomerase reverse transcriptase | 0.069 | 0.2676 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.069 | 0.2676 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.069 | 0.2676 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.069 | 0.2676 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.01 | 0.0321 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0321 | 0.5 |
Loa Loa (eye worm) | NHE-3 | 0.01 | 0.0321 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.01 | 0.0321 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0055 | 0.0144 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.01 | 0.0321 | 1 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.01 | 0.0321 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0055 | 0.0144 | 0.5 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.01 | 0.0321 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.1836 | 0.7248 | 1 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.01 | 0.0321 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.069 | 0.2676 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.01 | 0.0321 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.069 | 0.2676 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0055 | 0.0144 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0321 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0055 | 0.0144 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.069 | 0.2676 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0055 | 0.0144 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0055 | 0.0144 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.069 | 0.2676 | 1 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.01 | 0.0321 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.01 | 0.0321 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.01 | 0.0321 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.01 | 0.0321 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.01 | 0.0321 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.01 | 0.0321 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.01 | 0.0321 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.1 nM | Inhibition of NHE1-mediated rat platelet swelling | ChEMBL. | 19433354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.