Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | thymidylate kinase | 0.0457 | 0.1291 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.0457 | 0.1291 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0457 | 0.1291 | 0.5 |
Echinococcus granulosus | thymidylate kinase | 0.0457 | 0.1291 | 0.3703 |
Schistosoma mansoni | thymidylate kinase | 0.0457 | 0.1291 | 0.3703 |
Giardia lamblia | Hypothetical protein | 0.0878 | 0.3249 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0878 | 0.3249 | 1 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0457 | 0.1291 | 0.1168 |
Brugia malayi | thymidylate kinase | 0.0457 | 0.1291 | 0.3703 |
Loa Loa (eye worm) | thymidylate kinase | 0.0457 | 0.1291 | 1 |
Plasmodium falciparum | thymidylate kinase | 0.0457 | 0.1291 | 0.5 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0457 | 0.1291 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0878 | 0.3249 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0457 | 0.1291 | 0.3703 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0878 | 0.3249 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0457 | 0.1291 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0878 | 0.3249 | 1 |
Echinococcus granulosus | Transglutaminase | 0.0878 | 0.3249 | 1 |
Brugia malayi | Thioredoxin family protein | 0.0878 | 0.3249 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0878 | 0.3249 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0878 | 0.3249 | 1 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0878 | 0.3249 | 1 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0878 | 0.3249 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0878 | 0.3249 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0457 | 0.1291 | 0.3703 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0878 | 0.3249 | 1 |
Plasmodium vivax | thymidylate kinase, putative | 0.0457 | 0.1291 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0457 | 0.1291 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0878 | 0.3249 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0878 | 0.3249 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0457 | 0.1291 | 0.5 |
Toxoplasma gondii | thymidylate kinase | 0.0457 | 0.1291 | 0.5 |
Mycobacterium tuberculosis | Long conserved protein | 0.0878 | 0.3249 | 1 |
Echinococcus multilocularis | Transglutaminase | 0.0878 | 0.3249 | 1 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0878 | 0.3249 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0457 | 0.1291 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0457 | 0.1291 | 0.5 |
Echinococcus multilocularis | thymidylate kinase | 0.0457 | 0.1291 | 0.3703 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 338 nM | Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cells | ChEMBL. | 12801240 |
IC50 (binding) | = 338 nM | Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cells | ChEMBL. | 12801240 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.