Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.036 | 0.0251 | 0.0293 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0194 | 0.0083 | 0.0278 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0194 | 0.0083 | 0.0267 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0115 | 0.0004 | 0.0012 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.0083 | 0.0094 |
Echinococcus multilocularis | insulin receptor | 0.0115 | 0.0004 | 0.0012 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.0083 | 0.0094 |
Brugia malayi | Protein kinase domain containing protein | 0.8478 | 0.8457 | 0.8456 |
Echinococcus granulosus | epidermal growth factor receptor | 0.036 | 0.0251 | 0.0833 |
Onchocerca volvulus | Diphthamide biosynthesis protein 7 homolog | 0.3058 | 0.2978 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0081 | 0.0091 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0081 | 0.0091 |
Schistosoma mansoni | serine/threonine protein kinase | 0.8478 | 0.8457 | 1 |
Echinococcus multilocularis | Cyclin dependent kinase 2 associated protein | 0.3058 | 0.2978 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.8478 | 0.8457 | 1 |
Schistosoma mansoni | deleted in oral cancer 1/cdk2-associated protein-like | 0.3058 | 0.2978 | 0.3519 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0194 | 0.0083 | 0.0267 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.036 | 0.0251 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.3058 | 0.2978 | 0.3519 |
Schistosoma mansoni | tyrosine kinase | 0.036 | 0.0251 | 0.0293 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0081 | 0.0091 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.036 | 0.0251 | 0.0248 |
Echinococcus granulosus | Cyclin dependent kinase 2 associated protein | 0.3058 | 0.2978 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.009 uM | Inhibition of cell growth of SKBr3 cell lines using cell-based assay | ChEMBL. | 11495584 |
IC50 (functional) | = 0.009 uM | Inhibition of cell growth of SKBr3 cell lines using cell-based assay | ChEMBL. | 11495584 |
IC50 (binding) | = 0.065 uM | Inhibition of epidermal growth factor receptor using enzyme assay | ChEMBL. | 11495584 |
IC50 (binding) | = 0.065 uM | Inhibition of epidermal growth factor receptor using enzyme assay | ChEMBL. | 11495584 |
IC50 (functional) | = 0.077 uM | Inhibition of cell growth of human epidermoid carcinoma xenograft (A431) model using cell based assay | ChEMBL. | 11495584 |
IC50 (functional) | = 0.077 uM | Inhibition of cell growth of human epidermoid carcinoma xenograft (A431) model using cell based assay | ChEMBL. | 11495584 |
IC50 (binding) | = 0.116 uM | Inhibition of human epidermal growth factor receptor (HER-2) using enzyme assay | ChEMBL. | 11495584 |
IC50 (binding) | = 0.116 uM | Inhibition of human epidermal growth factor receptor (HER-2) using enzyme assay | ChEMBL. | 11495584 |
IC50 (functional) | = 0.945 uM | Inhibition of cell growth of SW620 cell lines using cell-based assay | ChEMBL. | 11495584 |
IC50 (functional) | = 0.945000000000001 uM | Inhibition of cell growth of SW620 cell lines using cell-based assay | ChEMBL. | 11495584 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11495584 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.