Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0101 | 0.1711 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0106 | 0.1896 | 0.1896 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.5389 |
Brugia malayi | thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0222 | 0.6067 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Echinococcus granulosus | insulin receptor | 0.0106 | 0.1896 | 0.1896 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0222 | 0.6067 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0101 | 0.1711 | 0.1711 |
Onchocerca volvulus | 0.0101 | 0.1711 | 0.7187 | |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0331 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.6939 | 0.6939 |
Echinococcus multilocularis | 0.0103 | 0.1777 | 0.1777 | |
Echinococcus granulosus | serotonin transporter | 0.0101 | 0.1711 | 0.1711 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0119 | 0.2381 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0101 | 0.1711 | 0.1711 |
Schistosoma mansoni | tyrosine kinase | 0.0178 | 0.449 | 0.449 |
Onchocerca volvulus | 0.0119 | 0.2381 | 1 | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0246 | 0.6939 | 0.6939 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0132 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0101 | 0.1711 | 0.1711 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0222 | 0.6067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1711 | 0.1711 |
Schistosoma mansoni | tyrosine kinase | 0.0178 | 0.449 | 0.449 |
Echinococcus granulosus | geminin | 0.0188 | 0.4856 | 0.4856 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0178 | 0.449 | 0.449 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.5389 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0222 | 0.6067 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0106 | 0.1896 | 0.1896 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0246 | 0.6939 | 0.6939 |
Echinococcus granulosus | thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Schistosoma mansoni | tyrosine kinase | 0.0106 | 0.1896 | 0.1896 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0106 | 0.1896 | 0.1896 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0178 | 0.449 | 0.449 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0178 | 0.449 | 0.449 |
Schistosoma mansoni | tyrosine kinase | 0.0331 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0246 | 0.6939 | 0.6939 |
Echinococcus multilocularis | geminin | 0.0188 | 0.4856 | 0.4856 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0101 | 0.1711 | 0.1711 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0106 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0101 | 0.1711 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1711 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1711 | 0.1711 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Brugia malayi | amidase | 0.0246 | 0.6939 | 0.6939 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.4422 | 0.4422 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.4856 | 0.4856 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0101 | 0.1711 | 0.1711 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0246 | 0.6939 | 0.6939 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.6736 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.4422 | 0.4422 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0132 | 0.0132 |
Echinococcus multilocularis | thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0331 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0117 | 0.2292 | 0.9606 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.4856 | 0.4856 |
Brugia malayi | Protein kinase domain containing protein | 0.0106 | 0.1896 | 0.1896 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0105 | 0.1866 | 0.2922 |
Mycobacterium ulcerans | thymidylate synthase | 0.0119 | 0.2381 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0106 | 0.1896 | 0.1896 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.4422 | 0.4422 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0331 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0246 | 0.6939 | 0.6939 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0119 | 0.2381 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0101 | 0.1711 | 0.1711 |
Schistosoma mansoni | amidase | 0.0246 | 0.6939 | 0.6939 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0168 | 0.413 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.009 uM | Inhibition of human FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarin | ChEMBL. | 21392988 |
IC50 (binding) | = 0.01 uM | Inhibition of rat FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarin | ChEMBL. | 21392988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.