Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.3447 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0049 | 0.2024 | 0.2024 |
Entamoeba histolytica | hexokinase 2 | 0.0158 | 1 | 0.5 |
Onchocerca volvulus | 0.0158 | 1 | 1 | |
Brugia malayi | hexokinase type II | 0.005 | 0.2122 | 0.2122 |
Trypanosoma cruzi | hexokinase, putative | 0.0158 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0073 | 0.3799 | 0.3799 |
Echinococcus granulosus | hexokinase | 0.0158 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0049 | 0.2024 | 0.2024 |
Loa Loa (eye worm) | hexokinase type II | 0.0158 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0158 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0158 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0158 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0158 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0073 | 0.3799 | 0.3799 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0073 | 0.3799 | 0.3799 |
Brugia malayi | Hexokinase family protein | 0.0099 | 0.5696 | 0.5696 |
Plasmodium falciparum | hexokinase | 0.0158 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0158 | 1 | 1 |
Onchocerca volvulus | 0.0158 | 1 | 1 | |
Echinococcus granulosus | hexokinase type 2 | 0.0158 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0158 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.3447 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.429 | 0.429 |
Echinococcus multilocularis | hexokinase | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3093 | 0.3093 |
Echinococcus multilocularis | hexokinase | 0.0158 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0158 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0158 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0158 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0099 | 0.5696 | 0.5696 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.6328 | 0.6328 |
Treponema pallidum | hexokinase (hxk) | 0.0158 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0158 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2122 | 0.2122 |
Echinococcus multilocularis | hexokinase type 2 | 0.0158 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0158 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0073 | 0.3799 | 0.3799 |
Onchocerca volvulus | 0.0158 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.0158 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0158 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.429 | 0.429 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2122 | 0.2122 |
Echinococcus granulosus | hexokinase | 0.0158 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.