Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0406 | 0.2897 | 0.4947 |
Onchocerca volvulus | 0.0066 | 0 | 0.5 | |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0406 | 0.2897 | 0.4947 |
Onchocerca volvulus | Peroxidase homolog | 0.0066 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0753 | 0.5856 | 1 |
Brugia malayi | CHE-14 protein | 0.0167 | 0.0864 | 0.0864 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0167 | 0.0864 | 0.1476 |
Echinococcus multilocularis | protein patched | 0.0167 | 0.0864 | 0.1476 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.019 | 0.1062 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0406 | 0.2897 | 0.2933 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1225 | 0.9876 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0406 | 0.2897 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0753 | 0.5856 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0066 | 0 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0167 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2897 | 0.2897 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0066 | 0 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0167 | 0.0864 | 0.1476 |
Onchocerca volvulus | 0.0066 | 0 | 0.5 | |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0753 | 0.5856 | 0.5856 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0406 | 0.2897 | 0.2897 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0406 | 0.2897 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0167 | 0.0864 | 0.0875 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.019 | 0.1062 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.019 | 0.1062 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0167 | 0.0864 | 0.1476 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0406 | 0.2897 | 0.5 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0223 | 0.1339 | 0.1356 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0167 | 0.0864 | 0.1476 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0406 | 0.2897 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.124 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0753 | 0.5856 | 0.5856 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0167 | 0.0864 | 0.1476 |
Onchocerca volvulus | Peroxidasin homolog | 0.0066 | 0 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.019 | 0.1062 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0066 | 0 | 0.5 | |
Schistosoma mansoni | patched 1 | 0.0167 | 0.0864 | 0.0875 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0406 | 0.2897 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0066 | 0 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0167 | 0.0864 | 0.1476 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0753 | 0.5856 | 0.5929 |
Onchocerca volvulus | Dual oxidase homolog | 0.0066 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 40 mg kg-1 | Anti-tetrabenazine (TBZ) activity, ability to prevent TBZ-induced ptosis in mice | ChEMBL. | 6471069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.