TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 314.339 | Formula: C16H18N4O3
H donors: 2 H acceptors: 3 LogP: 0.5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CN1C(=O)CNC(=O)[C@H]1Cc1c[nH]cn1
InChi: 1S/C16H18N4O3/c1-23-13-4-2-11(3-5-13)9-20-14(6-12-7-17-10-19-12)16(22)18-8-15(20)21/h2-5,7,10,14H,6,8-9H2,1H3,(H,17,19)(H,18,22)/t14-/m1/s1
InChiKey: YVXRMUAIANZBCJ-CQSZACIVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	myosin xvIII	0.0047	0.2814	0.2814
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.1925	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	neuropeptide receptor A26	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	Dopamine receptor	0.0047	0.2814	0.784
Trypanosoma cruzi	adenylosuccinate synthetase, putative	0.0057	0.3589	0.5
Echinococcus granulosus	g protein coupled receptor	0.0047	0.2814	0.784
Echinococcus granulosus	allatostatin A receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	adenylosuccinate synthetase	0.0057	0.3589	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Echinococcus granulosus	somatostatin receptor	0.0047	0.2814	0.784
Brugia malayi	Dopamine receptor protein 2	0.0047	0.2814	0.784
Schistosoma mansoni	growth hormone secretagogue receptor	0.0047	0.2814	0.2814
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.2814	0.784
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.2814	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Leishmania major	adenylosuccinate synthetase, putative	0.0057	0.3589	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Loa Loa (eye worm)	TYRA-2 protein	0.0047	0.2814	0.784
Brugia malayi	larval opioid receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.2814	0.784
Brugia malayi	putative neuropeptide receptor	0.0047	0.2814	0.784
Onchocerca volvulus	Adenylosuccinate synthetase homolog	0.0057	0.3589	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	follicle stimulating hormone receptor	0.0047	0.2814	0.784
Brugia malayi	GnHR receptor homolog	0.0047	0.2814	0.784
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	amine GPCR	0.0047	0.2814	0.2814
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0047	0.2814	0.784
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.024	0.0669
Echinococcus multilocularis	neuropeptide s receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.2814	0.784
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0047	0.2814	0.784
Echinococcus granulosus	orexin receptor type 2	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	somatostatin receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0011	0.024	0.0669
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.2097	0.5842
Brugia malayi	G-protein coupled receptor	0.0047	0.2814	0.784
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0047	0.2814	0.2814
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.2814	0.2814
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Trypanosoma brucei	RNA helicase, putative	0.0147	1	1
Schistosoma mansoni	opsin-like receptor	0.0047	0.2814	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.2814	0.784
Brugia malayi	G protein-coupled receptor	0.0047	0.2814	0.784
Schistosoma mansoni	adenoreceptor	0.0047	0.2814	0.2814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0047	0.2814	0.2814
Schistosoma mansoni	hypothetical protein	0.0047	0.2814	0.2814
Echinococcus multilocularis	serotonin receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	neuropeptide F receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	g-protein coupled receptor	0.0047	0.2814	0.784
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0047	0.2814	0.2814
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.2814	0.784
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.2814	0.2814
Brugia malayi	Serotonin receptor	0.0047	0.2814	0.784
Schistosoma mansoni	neuropeptide receptor	0.0047	0.2814	0.2814
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0047	0.2814	0.784
Echinococcus multilocularis	sex peptide receptor	0.0047	0.2814	0.784
Wolbachia endosymbiont of Brugia malayi	adenylosuccinate synthetase	0.0057	0.3589	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0047	0.2814	0.784
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0047	0.2814	0.2814
Echinococcus granulosus	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	putative neuropeptide receptor NPR1	0.0047	0.2814	0.784
Echinococcus granulosus	neuropeptide receptor	0.0047	0.2814	0.784
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Plasmodium vivax	adenylosuccinate synthetase, putative	0.0057	0.3589	0.5
Echinococcus granulosus	neuropeptide receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Toxoplasma gondii	adenylosuccinate synthetase, putative	0.0057	0.3589	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0047	0.2814	0.784
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0047	0.2814	0.2814
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Schistosoma mansoni	hypothetical protein	0.0047	0.2814	0.2814
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0047	0.2814	0.784
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.2814	0.784
Echinococcus granulosus	sex peptide receptor	0.0047	0.2814	0.784
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.1925	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.2814	0.784
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0047	0.2814	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.2097	0.5842
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Mycobacterium ulcerans	adenylosuccinate synthetase	0.0057	0.3589	0.5
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.2097	0.5842
Echinococcus multilocularis	G protein coupled receptor 139	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	orexin receptor type 2	0.0047	0.2814	0.784
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.024	0.0669
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Echinococcus multilocularis	g-protein coupled receptor	0.0047	0.2814	0.784
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Brugia malayi	sulfakinin receptor protein	0.0047	0.2814	0.784
Schistosoma mansoni	amine GPCR	0.0047	0.2814	0.2814
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.2814	0.784
Schistosoma mansoni	opsin-like receptor	0.0047	0.2814	0.2814
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.2814	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0047	0.2814	0.784
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.2814	0.784
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.2337	0.2337
Schistosoma mansoni	hypothetical protein	0.0047	0.2814	0.2814
Brugia malayi	RE15519p	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.2814	0.784
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Schistosoma mansoni	neuropeptide f receptor 76f	0.0047	0.2814	0.2814
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.2814	0.784
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.2337	0.2337
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1752	0.488
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.024	0.0669
Brugia malayi	AKH receptor	0.0047	0.2814	0.784
Brugia malayi	Melatonin receptor type 1A	0.0047	0.2814	0.784
Echinococcus granulosus	g protein coupled receptor	0.0047	0.2814	0.784
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.2814	0.784
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.2814	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0047	0.2814	0.784
Echinococcus granulosus	neuropeptide FF receptor 2	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	biogenic amine receptor	0.0047	0.2814	0.2814
Schistosoma mansoni	neuropeptide receptor	0.0047	0.2814	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	adenylosuccinate synthetase	0.0057	0.3589	0.3589
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.024	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	amine GPCR	0.0047	0.2814	0.2814
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.2814	0.784
Echinococcus granulosus	neuropeptide s receptor	0.0047	0.2814	0.784
Brugia malayi	adss-prov protein	0.0057	0.3589	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Mycobacterium tuberculosis	Probable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase)	0.0057	0.3589	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	biogenic amine receptor	0.0047	0.2814	0.2814
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.2814	0.784
Schistosoma mansoni	neuropeptide receptor	0.0047	0.2814	0.2814
Schistosoma mansoni	biogenic amine receptor	0.0047	0.2814	0.2814
Echinococcus multilocularis	allatostatin A receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.2814	0.784
Schistosoma mansoni	neuropeptide receptor	0.0047	0.2814	0.2814
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.2814	0.784
Brugia malayi	Serotonin receptor	0.0047	0.2814	0.784
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0047	0.2814	0.784
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Schistosoma mansoni	hypothetical protein	0.0047	0.2814	0.2814
Echinococcus multilocularis	dro:myosuppressin receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	melatonin receptor type 1A	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0047	0.2814	0.784
Schistosoma mansoni	histamine h1 receptor	0.0047	0.2814	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.024	0.0669
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.2814	0.2814
Brugia malayi	ORL1-like opioid receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0047	0.2814	0.784
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0047	0.2814	0.784
Trypanosoma cruzi	adenylosuccinate synthetase, putative	0.0057	0.3589	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0047	0.2814	0.784
Brugia malayi	Dopamine receptor protein 1	0.0047	0.2814	0.784
Echinococcus granulosus	7TM GPCR rhodopsin	0.0047	0.2814	0.784
Schistosoma mansoni	opsin-like receptor	0.0047	0.2814	0.2814
Echinococcus granulosus	neuropeptide receptor A26	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.2814	0.784
Mycobacterium leprae	Probable adenylosuccinate synthase PurA (IMP--aspartate ligase) (AdSS) (AMPSase)	0.0057	0.3589	0.5
Echinococcus granulosus	g protein coupled receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.2814	0.784
Plasmodium falciparum	adenylosuccinate synthetase	0.0057	0.3589	0.5
Brugia malayi	hypothetical protein	0.0047	0.2814	0.784
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.2097	0.5842
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0047	0.2814	0.2814
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0047	0.2814	0.784
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.2814	0.784
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2814	0.784
Schistosoma mansoni	amine GPCR	0.0047	0.2814	0.2814
Brugia malayi	G-protein coupled receptor	0.0047	0.2814	0.784
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.2814	0.2814
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0047	0.2814	0.784
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0047	0.2814	0.2814
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0047	0.2814	0.2814
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0047	0.2814	0.784
Echinococcus granulosus	adenylosuccinate synthetase	0.0057	0.3589	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.024	0.024
Loa Loa (eye worm)	adss-prov protein	0.0057	0.3589	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0047	0.2814	0.784
Echinococcus granulosus	serotonin receptor	0.0047	0.2814	0.784
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0047	0.2814	0.784
Echinococcus multilocularis	serotonin receptor	0.0047	0.2814	0.784
Echinococcus granulosus	fmrfamide receptor	0.0047	0.2814	0.784
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.2814	0.2814
Echinococcus granulosus	G protein coupled receptor 139	0.0047	0.2814	0.784
Brugia malayi	neuropeptide F receptor	0.0047	0.2814	0.784
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.2814	0.784
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0047	0.2814	0.784
Schistosoma mansoni	amine GPCR	0.0047	0.2814	0.2814
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.2814	0.2814
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0047	0.2814	0.784
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.2814	0.784
Echinococcus granulosus	dro:myosuppressin receptor	0.0047	0.2814	0.784
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.2814	0.784
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.2814	0.2814

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1783388

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1528438