Detailed information for compound 152858

Basic information

Technical information
  • TDR Targets ID: 152858
  • Name: 7-methoxy-N-phenylquinazolin-4-amine
  • MW: 251.283 | Formula: C15H13N3O
  • H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)ncnc2Nc1ccccc1
  • InChi: 1S/C15H13N3O/c1-19-12-7-8-13-14(9-12)16-10-17-15(13)18-11-5-3-2-4-6-11/h2-10H,1H3,(H,16,17,18)
  • InChiKey: LHBIFPBTEJYQLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-methoxy-N-phenyl-quinazolin-4-amine
  • 7-methoxy-N-phenyl-4-quinazolinamine
  • (7-methoxyquinazolin-4-yl)-phenyl-amine
  • PD153035 Analog 15

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.3555 1
Echinococcus granulosus epidermal growth factor receptor 0.018 0.3555 1
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Mycobacterium ulcerans bifunctional protein BirA 0.038 0.9261 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Brugia malayi biotin--acetyl-CoA-carboxylase ligase family protein 0.0089 0.0955 0.2577
Echinococcus multilocularis biotin protein ligase 0.0089 0.0955 0.2685
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0215 0.0468
Trypanosoma brucei Biotin--acetyl-CoA-carboxylase ligase, putative 0.0089 0.0955 0.5
Schistosoma mansoni tyrosine kinase 0.018 0.3555 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0215 0.0468
Chlamydia trachomatis hypothetical protein 0.0122 0.188 1
Leishmania major biotin/lipoate protein ligase-like protein 0.0089 0.0955 0.5
Schistosoma mansoni tyrosine kinase 0.0097 0.1173 0.32
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Mycobacterium leprae POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS 0.0063 0.0215 0.5
Loa Loa (eye worm) biotin protein ligase 1 0.0089 0.0955 0.2577
Treponema pallidum biotin--acetyl-CoA-carboxylase ligase 0.0406 1 0.5
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.0089 0.0955 0.5
Schistosoma mansoni tyrosine kinase 0.0096 0.1144 0.3117
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.1173 0.32
Echinococcus granulosus 5'partial|biotin protein ligase 0.0063 0.0215 0.0468
Plasmodium vivax biotin--[acetyl-CoA-carboxylase] synthetase, putative 0.0089 0.0955 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.1173 0.32
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.0089 0.0955 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.3555 1
Plasmodium falciparum biotin protein ligase, putative 0.0089 0.0955 0.5
Schistosoma mansoni tyrosine kinase 0.0097 0.1173 0.32
Schistosoma mansoni biotin-protein ligase 0.0089 0.0955 0.2577
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Echinococcus multilocularis insulin receptor 0.0058 0.0052 0.0145
Echinococcus multilocularis biotin protein ligase 0.0089 0.0955 0.2685
Echinococcus granulosus N terminal of biotin protein ligase 0.0122 0.188 0.522
Schistosoma mansoni tyrosine kinase 0.0096 0.1144 0.3117
Wolbachia endosymbiont of Brugia malayi biotin-(acetyl-CoA carboxylase) ligase 0.0089 0.0955 0.5
Echinococcus multilocularis N terminal of biotin protein ligase 0.0122 0.188 0.5289
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.1173 0.3299
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.3555 1
Schistosoma mansoni biotin-protein ligase 0.0122 0.188 0.522
Giardia lamblia Hypothetical protein 0.0089 0.0955 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Schistosoma mansoni tyrosine kinase 0.0096 0.1144 0.3117
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.188 1
Entamoeba histolytica biotin--acetyl-CoA-carboxylase ligase, putative 0.0089 0.0955 0.4882
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0052 0.0145
Plasmodium falciparum biotin--acetyl-CoA-carboxylase, putative 0.0089 0.0955 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 120 nM Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A431 cell vesicles ChEMBL. 8568816
IC50 (binding) = 120 nM Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A431 cell vesicles ChEMBL. 8568816

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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