Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0129 | 0.7417 | 0.7417 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0129 | 0.7417 | 0.7417 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0129 | 0.7417 | 0.7417 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0109 | 0.3615 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0144 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0129 | 0.7417 | 0.7417 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0129 | 0.7417 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0129 | 0.7417 | 0.7417 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0109 | 0.3615 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0109 | 0.3615 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0109 | 0.3615 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0103 | 0.2583 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0129 | 0.7417 | 0.7417 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0109 | 0.3615 | 0.3615 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0129 | 0.7417 | 0.7417 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0109 | 0.3615 | 0.3615 |
Chlamydia trachomatis | glutamine binding protein | 0.0103 | 0.2583 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0109 | 0.3615 | 0.3615 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0129 | 0.7417 | 0.7417 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0103 | 0.2583 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0129 | 0.7417 | 0.7417 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0144 | 1 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0103 | 0.2583 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0103 | 0.2583 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0129 | 0.7417 | 0.7417 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0103 | 0.2583 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.