Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0139 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0126 | 0.7417 | 0.7417 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0106 | 0.3615 | 0.3615 |
Chlamydia trachomatis | glutamine binding protein | 0.01 | 0.2583 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0106 | 0.3615 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0106 | 0.3615 | 0.3615 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.01 | 0.2583 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0139 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0126 | 0.7417 | 0.7417 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0126 | 0.7417 | 0.7417 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0126 | 0.7417 | 0.7417 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0106 | 0.3615 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.01 | 0.2583 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0126 | 0.7417 | 0.7417 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0126 | 0.7417 | 0.7417 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0126 | 0.7417 | 0.7417 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0106 | 0.3615 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0126 | 0.7417 | 0.7417 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.01 | 0.2583 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0126 | 0.7417 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0106 | 0.3615 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0126 | 0.7417 | 0.7417 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0106 | 0.3615 | 0.3615 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.01 | 0.2583 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.01 | 0.2583 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0126 | 0.7417 | 0.7417 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.