Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hexokinase type II | 0.0367 | 0.2977 | 0.2977 |
Leishmania major | hexokinase, putative | 0.1154 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0107 | 0.0662 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.1154 | 1 | 0.5 |
Onchocerca volvulus | 0.1154 | 1 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0115 | 0.0729 | 0.0729 |
Schistosoma mansoni | hexokinase | 0.1154 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0357 | 0.2889 | 0.2889 |
Echinococcus granulosus | hexokinase | 0.1154 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1154 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1528 | 0.1528 |
Brugia malayi | Hexokinase family protein | 0.1154 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.1154 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0724 | 0.6163 | 0.6163 |
Echinococcus granulosus | geminin | 0.0205 | 0.1528 | 0.1528 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0107 | 0.0662 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.1154 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.1154 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1154 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1154 | 1 | 0.5 |
Onchocerca volvulus | 0.1154 | 1 | 1 | |
Plasmodium falciparum | hexokinase | 0.1154 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.1154 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.1154 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.1154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.2977 | 0.2977 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0115 | 0.0729 | 0.0729 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0115 | 0.0729 | 0.0729 |
Loa Loa (eye worm) | hexokinase | 0.1154 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0594 | 0.0594 |
Echinococcus multilocularis | hexokinase | 0.1154 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0115 | 0.0729 | 0.0729 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0126 | 0.0824 | 0.0824 |
Trypanosoma cruzi | hexokinase, putative | 0.1154 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.1154 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0126 | 0.0824 | 0.0824 |
Echinococcus multilocularis | hexokinase type 2 | 0.1154 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1154 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0357 | 0.2889 | 0.2889 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.2977 | 0.2977 |
Toxoplasma gondii | hexokinase | 0.1154 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0787 | 0.6726 | 0.6726 |
Entamoeba histolytica | hexokinase 2 | 0.1154 | 1 | 0.5 |
Onchocerca volvulus | 0.1154 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase type II | 0.1154 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0724 | 0.6163 | 0.6163 |
Echinococcus granulosus | hexokinase | 0.1154 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1154 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] | ChEMBL. | No reference |
Potency (functional) | 2.5929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.