Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0274 | 0.1222 | 0.1222 |
Onchocerca volvulus | 0.1855 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.1855 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0274 | 0.1222 | 0.1222 |
Toxoplasma gondii | hexokinase | 0.1855 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.1855 | 1 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel | 0.008 | 0.014 | 0.014 |
Loa Loa (eye worm) | hexokinase | 0.0574 | 0.2886 | 0.2886 |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 0.2974 | 0.2974 |
Treponema pallidum | hexokinase (hxk) | 0.1855 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.008 | 0.014 | 0.014 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.1855 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.1855 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.03 | 0.1362 | 0.1362 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.1265 | 0.6725 | 0.6725 |
Echinococcus multilocularis | hexokinase type 2 | 0.1855 | 1 | 1 |
Onchocerca volvulus | 0.1855 | 1 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.008 | 0.014 | 0.014 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hexokinase | 0.1855 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0005 | 0.0005 |
Brugia malayi | Hexokinase family protein | 0.1164 | 0.6161 | 0.6161 |
Plasmodium falciparum | hexokinase | 0.1855 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0005 | 0.0005 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0256 | 0.1122 | 1 |
Plasmodium vivax | hexokinase, putative | 0.1855 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.1855 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.059 | 0.2974 | 0.2974 |
Trypanosoma cruzi | hexokinase, putative | 0.1855 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.014 | 0.014 |
Trypanosoma brucei | hexokinase | 0.1855 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0274 | 0.1222 | 0.1222 |
Entamoeba histolytica | hexokinase 1 | 0.1855 | 1 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0005 | 0.0005 |
Brugia malayi | Hexokinase family protein | 0.0574 | 0.2886 | 0.2886 |
Echinococcus granulosus | hexokinase | 0.1855 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1855 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1855 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1855 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.1855 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.1855 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.1855 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.1855 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.1855 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.1855 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.1164 | 0.6161 | 0.6161 |
Schistosoma mansoni | voltage-gated potassium channel | 0.03 | 0.1362 | 0.1362 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0005 | 0.0005 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0005 | 0.0005 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.014 | 0.014 |
Echinococcus granulosus | hexokinase | 0.1855 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.1855 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0274 | 0.1222 | 0.1222 |
Echinococcus multilocularis | voltage gated potassium channel | 0.008 | 0.014 | 0.014 |
Echinococcus multilocularis | hexokinase | 0.1855 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.008 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 0.2974 | 0.2974 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1021 | 0.1021 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0256 | 0.1122 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.