Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1235 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.1235 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.1235 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.1235 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.1235 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0555 | 0.0555 |
Echinococcus granulosus | hexokinase type 2 | 0.1235 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0115 | 0.0682 | 0.0682 |
Echinococcus granulosus | hexokinase | 0.1235 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0115 | 0.0682 | 0.0682 |
Toxoplasma gondii | hexokinase | 0.1235 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0115 | 0.0682 | 0.0682 |
Entamoeba histolytica | hexokinase 1 | 0.1235 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0382 | 0.2902 | 0.2902 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.299 | 0.299 |
Plasmodium vivax | hexokinase, putative | 0.1235 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.1235 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0382 | 0.2902 | 0.2902 |
Brugia malayi | hexokinase type II | 0.0393 | 0.299 | 0.299 |
Loa Loa (eye worm) | hexokinase type II | 0.1235 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0775 | 0.617 | 0.617 |
Brugia malayi | Hexokinase family protein | 0.0775 | 0.617 | 0.617 |
Echinococcus multilocularis | hexokinase | 0.1235 | 1 | 1 |
Onchocerca volvulus | 0.1235 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.1235 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.1235 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.1235 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.1235 | 1 | 1 |
Onchocerca volvulus | 0.1235 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0842 | 0.6732 | 0.6732 |
Schistosoma mansoni | hexokinase | 0.1235 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.299 | 0.299 |
Leishmania major | hexokinase, putative | 0.1235 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0126 | 0.0771 | 0.0771 |
Brugia malayi | Hexokinase family protein | 0.1235 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0108 | 0.0619 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0115 | 0.0682 | 0.0682 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0126 | 0.0771 | 0.0771 |
Echinococcus multilocularis | hexokinase | 0.1235 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1235 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1235 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.1235 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.1235 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1235 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.1235 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0108 | 0.0619 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.