Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein Malvolio homolog | 0.0504 | 0.3962 | 0.5 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0504 | 0.3962 | 0.5 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0504 | 0.3962 | 1 |
Plasmodium vivax | metal transporter, putative | 0.0504 | 0.3962 | 0.5 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0504 | 0.3962 | 0.5 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0504 | 0.3962 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.3962 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.3962 | 0.5 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0504 | 0.3962 | 0.5 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0312 | 0.1514 | 1 |
Plasmodium falciparum | transporter, putative | 0.0504 | 0.3962 | 0.5 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0504 | 0.3962 | 0.5 |
Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0312 | 0.1514 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3535 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.