Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.058 | 1 | 0.5 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0359 | 0.3861 | 1 |
Plasmodium falciparum | transporter, putative | 0.058 | 1 | 0.5 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.058 | 1 | 0.5 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.058 | 1 | 0.5 |
Mycobacterium ulcerans | divalent cation-transport integral membrane protein | 0.0222 | 0.0065 | 0.0065 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.058 | 1 | 0.5 |
Mycobacterium ulcerans | divalent cation-transport integral membrane protein | 0.0222 | 0.0065 | 0.0065 |
Toxoplasma gondii | divalent metal transporter, putative | 0.058 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 1 | 0.5 |
Mycobacterium leprae | possible membrane transport protein | 0.0222 | 0.0065 | 0.0168 |
Plasmodium vivax | metal transporter, putative | 0.058 | 1 | 0.5 |
Onchocerca volvulus | Protein Malvolio homolog | 0.058 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 1 | 0.5 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.058 | 1 | 1 |
Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0359 | 0.3861 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.