Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.0554 | 0.0554 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.0462 | 0.6703 |
Echinococcus granulosus | jun protein | 0.0088 | 0.0973 | 0.8597 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.026 | 0.4002 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.0462 | 0.6703 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0096 | 0.0019 |
Loa Loa (eye worm) | matrixin family protein | 0.0058 | 0.0462 | 0.0462 |
Leishmania major | squalene monooxygenase-like protein | 0.026 | 0.4002 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0096 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0096 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.1777 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.026 | 0.4002 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0096 | 0.1116 | 1 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.026 | 0.4002 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0096 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0071 | 0.0686 | 0.3521 |
Brugia malayi | bZIP transcription factor family protein | 0.0088 | 0.0973 | 0.0973 |
Echinococcus multilocularis | jun protein | 0.0088 | 0.0973 | 0.8597 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0686 | 0.3521 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0931 | 0.0931 |
Brugia malayi | Hemopexin family protein | 0.0037 | 0.0092 | 0.0092 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0096 | 0.0096 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 0.1116 | 1 |
Brugia malayi | hypothetical protein | 0.0069 | 0.0643 | 0.0643 |
Mycobacterium ulcerans | hydrolase | 0.0032 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0088 | 0.0973 | 0.8597 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0096 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.0554 | 0.0554 |
Onchocerca volvulus | 0.0069 | 0.0643 | 1 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0088 | 0.0973 | 0.8597 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0096 | 0.0019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.