Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0343 | 0.0343 |
Brugia malayi | GH02984p | 0.0226 | 0.252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Schistosoma mansoni | inositol transporter | 0.0887 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0068 | 0.0732 | 0.0732 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.004 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0322 | 0.0322 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.007 | 0.0022 |
Schistosoma mansoni | inositol transporter | 0.0887 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0887 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.004 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.0343 | 0.0297 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.004 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.1858 | 0.7302 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0226 | 0.252 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0226 | 0.252 | 0.2484 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0343 | 0.0343 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Onchocerca volvulus | 0.0226 | 0.252 | 1 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0009 | 0.0009 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1858 | 0.7301 |
Schistosoma mansoni | high-affinity choline transporter | 0.0226 | 0.252 | 0.252 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0226 | 0.252 | 0.2484 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.004 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.004 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.1858 | 0.1819 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.0322 | 0.1036 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0887 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1858 | 0.7301 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.004 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0226 | 0.252 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0887 | 1 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0048 | 0.0048 |
Echinococcus granulosus | solute carrier family 5 | 0.0887 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.1858 | 0.1819 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.0343 | 0.0297 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.1858 | 0.1819 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.252 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.0226 | 0.252 | 0.252 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0887 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.252 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0887 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.004 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.0322 | 0.1031 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0226 | 0.252 | 0.2484 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.004 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0226 | 0.252 | 0.2484 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.004 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.004 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.007 | 0.0022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.