Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | heat shock protein 90 | 0.1109 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1392 | 1 | 1 |
Schistosoma mansoni | heat shock protein | 0.1392 | 1 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.1109 | 0.655 | 0.655 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.1109 | 0.655 | 0.655 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.1392 | 1 | 1 |
Loa Loa (eye worm) | heat shock protein 90 | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Mycobacterium ulcerans | heat shock protein 90 | 0.1109 | 0.655 | 0.5 |
Plasmodium vivax | endoplasmin, putative | 0.1392 | 1 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1392 | 1 | 1 |
Echinococcus granulosus | endoplasmin | 0.1109 | 0.655 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.1392 | 1 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.1392 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.1109 | 0.655 | 0.655 |
Schistosoma mansoni | endoplasmin | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.1392 | 1 | 1 |
Brugia malayi | heat shock protein 90 | 0.1392 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1392 | 1 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0854 | 0.345 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.1109 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Echinococcus multilocularis | heat shock protein | 0.1392 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.1392 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.1109 | 0.655 | 0.655 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.1109 | 0.655 | 0.655 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.1392 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.1109 | 0.655 | 0.655 |
Entamoeba histolytica | heat shock protein 90, putative | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1392 | 1 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0854 | 0.345 | 0.345 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.1109 | 0.655 | 0.655 |
Echinococcus multilocularis | endoplasmin | 0.1109 | 0.655 | 0.655 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.1109 | 0.655 | 0.5 |
Echinococcus granulosus | heat shock protein 90 | 0.1392 | 1 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.1392 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.1392 | 1 | 1 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.057 | 0 | 0.5 |
Trypanosoma brucei | heat shock protein 90, putative | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0854 | 0.345 | 0.345 |
Schistosoma mansoni | heat shock protein | 0.1392 | 1 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.1109 | 0.655 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.1392 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.1109 | 0.655 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.1392 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.1392 | 1 | 1 |
Echinococcus granulosus | heat shock protein | 0.1392 | 1 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.1392 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.1392 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.1109 | 0.655 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.1392 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.1392 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1392 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0822 | 0.3058 | 0.3058 |
Plasmodium falciparum | heat shock protein 90 | 0.1392 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.3 nM | Binding affinity to human Tachykinin receptor 1 | ChEMBL. | No reference |
IC50 (binding) | = 4.3 nM | Binding affinity to human Tachykinin receptor 1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.