Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fli-1 protein | 0.0231 | 0.2616 | 0.8168 |
Trichomonas vaginalis | glutaminase, putative | 0.0281 | 0.3202 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0076 | 0.0774 | 0.2416 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0289 | 0.3296 | 0.5 |
Schistosoma mansoni | gabp alpha | 0.0076 | 0.0774 | 0.2416 |
Loa Loa (eye worm) | glutaminase | 0.0281 | 0.3202 | 1 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0289 | 0.3296 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0642 | 0.2006 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0289 | 0.3296 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0231 | 0.2616 | 0.8168 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0289 | 0.3296 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0076 | 0.0774 | 0.0774 |
Brugia malayi | glutaminase DH11.1 | 0.0281 | 0.3202 | 1 |
Treponema pallidum | hypothetical protein | 0.0289 | 0.3296 | 0.5 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0289 | 0.3296 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0076 | 0.0774 | 0.2416 |
Brugia malayi | Ets-domain containing protein | 0.0076 | 0.0774 | 0.2416 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0076 | 0.0774 | 1 |
Schistosoma mansoni | glutaminase | 0.0281 | 0.3202 | 1 |
Schistosoma mansoni | ets-related | 0.0231 | 0.2616 | 0.8168 |
Loa Loa (eye worm) | glutaminase 2 | 0.0281 | 0.3202 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.