Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | clathrin heavy chain, putative | 0.0262 | 0.2205 | 0.5 |
Loa Loa (eye worm) | clathrin | 0.0432 | 0.4055 | 1 |
Echinococcus granulosus | clathrin heavy chain | 0.0432 | 0.4055 | 0.5 |
Schistosoma mansoni | clathrin heavy chain | 0.012 | 0.0667 | 0.5 |
Plasmodium vivax | clathrin heavy chain, putative | 0.0291 | 0.2517 | 0.5 |
Trypanosoma cruzi | clathrin heavy chain, putative | 0.0262 | 0.2205 | 1 |
Plasmodium falciparum | clathrin heavy chain, putative | 0.0229 | 0.185 | 0.5 |
Trypanosoma brucei | clathrin heavy chain, putative | 0.0262 | 0.2205 | 1 |
Trypanosoma brucei | clathrin heavy chain | 0.0262 | 0.2205 | 1 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0232 | 0.1878 | 0.7459 |
Brugia malayi | Probable clathrin heavy chain | 0.0432 | 0.4055 | 1 |
Giardia lamblia | Clathrin heavy chain | 0.012 | 0.0667 | 0.5 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0291 | 0.2517 | 1 |
Trichomonas vaginalis | clathrin heavy chain, putative | 0.0068 | 0.0102 | 1 |
Toxoplasma gondii | clathrin heavy chain, putative | 0.012 | 0.0667 | 0.5 |
Schistosoma mansoni | clathrin heavy chain | 0.012 | 0.0667 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3489 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.