Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | clathrin heavy chain, putative | 0.0197 | 0.1929 | 0.7459 |
Schistosoma mansoni | clathrin heavy chain | 0.0102 | 0.0685 | 0.0445 |
Trypanosoma cruzi | clathrin heavy chain, putative | 0.0223 | 0.2265 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0812 | 1 | 1 |
Schistosoma mansoni | clathrin heavy chain | 0.0102 | 0.0685 | 0.0445 |
Echinococcus multilocularis | clathrin heavy chain | 0.0368 | 0.4165 | 0.4015 |
Trypanosoma brucei | clathrin heavy chain | 0.0223 | 0.2265 | 1 |
Giardia lamblia | Clathrin heavy chain | 0.0102 | 0.0685 | 0.5 |
Echinococcus granulosus | clathrin heavy chain | 0.0368 | 0.4165 | 0.4015 |
Plasmodium vivax | clathrin heavy chain, putative | 0.0247 | 0.2586 | 0.5 |
Trichomonas vaginalis | clathrin heavy chain, putative | 0.0058 | 0.0105 | 1 |
Brugia malayi | Probable clathrin heavy chain | 0.0368 | 0.4165 | 1 |
Toxoplasma gondii | clathrin heavy chain, putative | 0.0102 | 0.0685 | 0.5 |
Leishmania major | clathrin heavy chain, putative | 0.0223 | 0.2265 | 0.5 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0247 | 0.2586 | 1 |
Trypanosoma brucei | clathrin heavy chain, putative | 0.0223 | 0.2265 | 1 |
Plasmodium falciparum | clathrin heavy chain, putative | 0.0195 | 0.19 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0812 | 1 | 1 |
Loa Loa (eye worm) | clathrin | 0.0368 | 0.4165 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 56.2341 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.