Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1356 | 1 | 1 |
Schistosoma mansoni | Smad4 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1356 | 1 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0998 | 0.0998 |
Echinococcus multilocularis | Smad4 | 0.001 | 0 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.001 | 0 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0 | 0.5 |
Echinococcus granulosus | Smad4 | 0.001 | 0 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0 | 0.5 |
Echinococcus granulosus | smad | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.001 | 0 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.001 | 0 | 0.5 |
Schistosoma mansoni | smad | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | smad | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1356 | 1 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0998 | 0.0998 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0998 | 0.0998 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.