Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.5598 | 0.5598 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 1 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 1 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 1 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 1 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 1 | 0.5 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 1 | 0.5 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 19.957 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 29.187 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.0026 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.