pI: 6.1317 |
Length (AA): 773 |
MW (Da): 86911 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
235 | 767 | 5tqu (B) | 235 | 767 | 99.00 | 0 | 1 | 1.88552 | -1.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127468)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G55400 | methionyl-tRNA synthetase |
Babesia bovis | BBOV_I001970 | methionyl-tRNA synthetase, putative |
Brugia malayi | Bm1_54415 | methionyl-tRNA synthetase |
Candida albicans | CaO19.3950 | mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase |
Candida albicans | CaO19.11432 | mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase |
Caenorhabditis elegans | CELE_Y105E8A.20 | Protein Y105E8A.20, isoform A |
Cryptosporidium hominis | Chro.80398 | methionine -- tRNA ligase |
Cryptosporidium parvum | cgd8_3460 | methionyl-tRNA synthetase of possible bacterial origin |
Dictyostelium discoideum | DDB_G0285759 | methionine-tRNA ligase |
Drosophila melanogaster | Dmel_CG31322 | Methionyl-tRNA synthetase |
Echinococcus granulosus | EgrG_000186800 | methionine tRNA synthetase |
Echinococcus multilocularis | EmuJ_000186800 | methionine tRNA synthetase |
Giardia lamblia | GL50803_22204 | Methionyl-tRNA synthetase |
Homo sapiens | ENSG00000247626 | methionyl-tRNA synthetase 2, mitochondrial |
Leishmania braziliensis | LbrM.21.0900 | methionyl-tRNA synthetase, putative |
Leishmania donovani | LdBPK_210890.1 | methionyl-tRNA synthetase, putative |
Leishmania infantum | LinJ.21.0890 | methionyl-tRNA synthetase, putative |
Leishmania major | LmjF.21.0810 | methionyl-tRNA synthetase, putative |
Leishmania mexicana | LmxM.21.0810 | methionyl-tRNA synthetase, putative |
Loa Loa (eye worm) | LOAG_10885 | tyrosyl-tRNA synthetase |
Loa Loa (eye worm) | LOAG_02240 | methionyl-tRNA synthetase |
Mycobacterium leprae | ML0238c | Probable methionyl-tRNA synthase MetS |
Mus musculus | 212679 | methionine-tRNA synthetase 2 (mitochondrial) |
Mycobacterium tuberculosis | Rv1007c | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) |
Mycobacterium ulcerans | MUL_4654 | methionyl-tRNA synthetase |
Neospora caninum | NCLIV_041650 | Methionine--tRNA ligase (EC 6.1.1.10), related |
Oryza sativa | 4332018 | Os03g0209600 |
Onchocerca volvulus | OVOC12840 |
|
Plasmodium berghei | PBANKA_0518700 | methionine--tRNA ligase, putative |
Plasmodium falciparum | PF3D7_1034900 | methionine--tRNA ligase |
Plasmodium knowlesi | PKNH_0620100 | methionine--tRNA ligase, putative |
Plasmodium vivax | PVX_110980 | methionine--tRNA ligase, putative |
Plasmodium yoelii | PY03894 | methionyl-tRNA synthetase |
Saccharomyces cerevisiae | YGR171C | methionine--tRNA ligase MSM1 |
Schistosoma japonicum | Sjp_0206550 | ko:K01874 methionyl-tRNA synthetase [EC6.1.1.10], putative |
Schistosoma mansoni | Smp_005330 | methionine-tRNA synthetase |
Schmidtea mediterranea | mk4.010622.00 | |
Schmidtea mediterranea | mk4.019340.01 | |
Schmidtea mediterranea | mk4.016299.00 | MethionineALQ-tRNA ligase, mitochondrial |
Schmidtea mediterranea | mk4.031319.00 | MethionineALQ-tRNA ligase, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.10.1750 | methionyl-tRNA synthetase, putative |
Trypanosoma brucei | Tb927.10.1500 | methionyl-tRNA synthetase, putative |
Trypanosoma congolense | TcIL3000_10_1300 | methionyl-tRNA synthetase, putative |
Trypanosoma cruzi | TcCLB.509247.50 | methionyl-tRNA synthetase, putative |
Toxoplasma gondii | TGME49_289300 | methionyl-tRNA synthetase |
Theileria parva | TP01_1212 | methionyl-tRNA synthetase, putative |
Theileria parva | TP03_0137 | methionyl-tRNA synthetase, putative |
Trichomonas vaginalis | TVAG_266630 | methionine-tRNA synthetase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0196 | methionyl-tRNA synthetase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1023 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.10.1500 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1500 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1500 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.1500 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y105E8A.20 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_289300 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.7
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Staphylococcus aureus subsp. aureus MW2 | Methionyl-tRNA synthetase | Compounds | References |
1 literature reference was collected for this gene.