Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA (cytosine-5)-methyltransferase | 0.0021 | 0.0306 | 0.0809 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0041 | 0.3111 | 0.8213 |
Echinococcus granulosus | disco interacting protein 2 | 0.0041 | 0.3111 | 0.8213 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0041 | 0.3111 | 0.8213 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.3788 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.3788 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.3788 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.3788 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.3788 | 1 |
Toxoplasma gondii | C-5 cytosine-specific DNA methylase superfamily protein | 0.0021 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0036 | 0.2362 | 0.6235 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.2362 | 0.6235 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.3788 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | DNA methyltransferase 2, putative | 0.0021 | 0.0306 | 0.0809 |
Plasmodium vivax | DNA (cytosine-5)-methyltransferase, putative | 0.0021 | 0.0306 | 1 |
Toxoplasma gondii | hypothetical protein | 0.009 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.2362 | 0.6235 |
Brugia malayi | CXXC zinc finger family protein | 0.0036 | 0.2362 | 0.6235 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0041 | 0.3111 | 0.8213 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.3788 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.2362 | 0.6235 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.3788 | 1 |
Plasmodium falciparum | DNA (cytosine-5)-methyltransferase | 0.0021 | 0.0306 | 0.0306 |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.0021 | 0.0306 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.2362 | 0.6235 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.3111 | 1 | |
Leishmania major | modification methylase-like protein | 0.0021 | 0.0306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3111 | 0.8213 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.0021 | 0.0306 | 1 |
Echinococcus multilocularis | DNA methyltransferase 2, putative | 0.0021 | 0.0306 | 0.0809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.3788 | 1 |
Toxoplasma gondii | DNA methyltransferase 2, putative | 0.0021 | 0.0306 | 0.0306 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.2362 | 0.6235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.